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H-Type Hypertension and C Reactive Protein in Recurrence of Ischemic Stroke

Author

Listed:
  • Qing Zhang

    (Institute of Public Health, School of Nursing, Henan University, Kaifeng 475004, China
    These authors contributed equally to this work.)

  • De-Xing Qiu

    (Guangming New District People’s Hospital & Community Health Service Management Center of Guangming Area, Shenzhen 518000, China
    These authors contributed equally to this work.)

  • Rong-Li Fu

    (Internal Medicine-Neurology, Huaihe Hospital, Henan University, Kaifeng 475000, China)

  • Tian-Fen Xu

    (Basical School, Guangzhou Medical University, Guangzhou 510180, China)

  • Meng-Juan Jing

    (Institute of Public Health, School of Nursing, Henan University, Kaifeng 475004, China)

  • Hui-Shan Zhang

    (Department of Preventive Medicine, School of Public Health, Guangzhou Medical University, Guangzhou 510180, China)

  • He-Hong Geng

    (Institute of Public Health, School of Nursing, Henan University, Kaifeng 475004, China)

  • Long-Chao Zheng

    (Department of Public Health, School of Public Health, Graduate School of Guizhou Medical University, Guiyang 550025, China)

  • Pei-Xi Wang

    (Institute of Public Health, School of Nursing, Henan University, Kaifeng 475004, China
    Department of Preventive Medicine, School of Public Health, Guangzhou Medical University, Guangzhou 510180, China)

Abstract

Hypertension with high homocysteine (HHcy) (H-type hypertension) and C reactive protein (CRP) can increase the incidence of ischemic stroke. However, it is not clear whether recurrent ischemic stroke (RIS) is related to H-type hypertension and CRP. The present study investigated the correlation of H-type hypertension and CRP level with RIS. Totally, 987 consecutive patients with acute ischemic stroke were recruited in a teaching hospital in Henan province, China during March 2014 to March 2015. The demographic and clinical characteristics and blood biochemical parameters of patients were analyzed. Elevated levels of CRP and homocysteine (Hcy) were defined as >8.2 mg/L and 10 μmol/L, respectively. Among the 987 patients, 234 were RIS. Thirty-eight percent of RIS patients had elevated CRP level and 91.5% of RIS patients had HHcy. In multivariate analysis, adjusted odds ratio (OR) of RIS in patients aged ≥60 years was 1.576 (95% CI: 1.125–2.207), in male patients 1.935 (95% CI: 1.385–2.704), in patients with diabetes 1.463 (95% CI: 1.037–2.064), CRP levels 1.013 (95% CI: 1.006–1.019), simple hypertension 3.370 (95% CI: 1.15–10.183), and H-type hypertension 2.990 (95% CI: 1.176–7.600). RIS was associated with older age, male, diabetes, H-type hypertension and CRP. Controlling H-type hypertension and CRP level may reduce the risk of RIS.

Suggested Citation

  • Qing Zhang & De-Xing Qiu & Rong-Li Fu & Tian-Fen Xu & Meng-Juan Jing & Hui-Shan Zhang & He-Hong Geng & Long-Chao Zheng & Pei-Xi Wang, 2016. "H-Type Hypertension and C Reactive Protein in Recurrence of Ischemic Stroke," IJERPH, MDPI, vol. 13(5), pages 1-9, May.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:5:p:477-:d:69631
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    Cited by:

    1. Ye Chang & Yuan Li & Xiaofan Guo & Yintao Chen & Dongxue Dai & Yingxian Sun, 2017. "The Prevalence of Hypertension Accompanied by High Homocysteine and its Risk Factors in a Rural Population: A Cross-Sectional Study from Northeast China," IJERPH, MDPI, vol. 14(4), pages 1-16, April.

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