IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v12y2015i7p8023-8033d52517.html
   My bibliography  Save this article

Matrix Metalloproteinase 9 Gene Promoter (rs 3918242) Mutation Reduces the Risk of Diabetic Microvascular Complications

Author

Listed:
  • Zhongwen Zhang

    (Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan 250014, China
    Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China)

  • Xiaoyun Wu

    (Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China)

  • Tian Cai

    (Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China)

  • Weiyi Gao

    (Department of Cadres Healthcare, Qilu Hospital of Shandong University, Qingdao 266035, China)

  • Xiaojun Zhou

    (Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China)

  • Junyu Zhao

    (Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China)

  • Jinming Yao

    (Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China)

  • Hongxia Shang

    (Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China)

  • Jianjun Dong

    (Division of Endocrinology, Department of Medicine, Qilu Hospital of Shandong University, Jinan 250012, China)

  • Lin Liao

    (Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China)

Abstract

Background: Many studies have evaluated the association between matrix metalloproteinase 9 (MMP9) gene promoter polymorphism and diabetic microvascular complications. However, the results are conflicting and inconclusive. The aim of this meta-analysis was to evaluate the association more precisely. Materials and Methods: Studies were retrieved from the PubMed, Embase, Medline, China National Knowledge Infrastructure, Web of Science, and Cochrane databases. All statistical analyses were performed using Review Manager 5.2. Results: Data were abstracted from four case-control studies that included 446 patients with diabetic microvascular complications and 496 diabetic control subjects. The MMP9-1562 C/T genotype was significantly associated with the risk of diabetic nephropathy after stratification by specific type of microvascular complication (CT + TT vs. CC: OR = 0.42, 95% CI = 0.26–0.69, p = 0.0006; TT vs. CC + CT: OR = 0.37, 95% CI = 0.19–0.76, p = 0.006). Conclusions: This study adds to the evidence that MMP9-1562 T gene mutation might reduce the risk of diabetic nephropathy.

Suggested Citation

  • Zhongwen Zhang & Xiaoyun Wu & Tian Cai & Weiyi Gao & Xiaojun Zhou & Junyu Zhao & Jinming Yao & Hongxia Shang & Jianjun Dong & Lin Liao, 2015. "Matrix Metalloproteinase 9 Gene Promoter (rs 3918242) Mutation Reduces the Risk of Diabetic Microvascular Complications," IJERPH, MDPI, vol. 12(7), pages 1-11, July.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:7:p:8023-8033:d:52517
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/12/7/8023/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/12/7/8023/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Shugang Li & Shuxia Guo & Fei He & Mei Zhang & Jia He & Yizhong Yan & Yusong Ding & Jingyu Zhang & Jiaming Liu & Heng Guo & Shangzhi Xu & Rulin Ma, 2015. "Prevalence of Diabetes Mellitus and Impaired Fasting Glucose, Associated with Risk Factors in Rural Kazakh Adults in Xinjiang, China," IJERPH, MDPI, vol. 12(1), pages 1-12, January.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ming Zhao & Hongbo Lin & Yanyan Yuan & Fuyan Wang & Yang Xi & Li Ming Wen & Peng Shen & Shizhong Bu, 2016. "Prevalence of Pre-Diabetes and Its Associated Risk Factors in Rural Areas of Ningbo, China," IJERPH, MDPI, vol. 13(8), pages 1-13, August.
    2. Jiangen Song & Xiaojuan Zha & Haibo Li & Rui Guo & Yu Zhu & Yufeng Wen, 2016. "Analysis of Blood Glucose Distribution Characteristics and Its Risk Factors among a Health Examination Population in Wuhu (China)," IJERPH, MDPI, vol. 13(4), pages 1-9, March.
    3. Norma Latif Fitriyani & Muhammad Syafrudin & Siti Maghfirotul Ulyah & Ganjar Alfian & Syifa Latif Qolbiyani & Muhammad Anshari, 2022. "A Comprehensive Analysis of Chinese, Japanese, Korean, US-PIMA Indian, and Trinidadian Screening Scores for Diabetes Risk Assessment and Prediction," Mathematics, MDPI, vol. 10(21), pages 1-23, October.
    4. Yulin Wang & Jingyu Zhang & Yusong Ding & Mei Zhang & Jiaming Liu & Jiaolong Ma & Heng Guo & Yizhong Yan & Jia He & Kui Wang & Shugang Li & Rulin Ma & Bek Murat & Shuxia Guo, 2016. "Prevalence of Hypertension among Adults in Remote Rural Areas of Xinjiang, China," IJERPH, MDPI, vol. 13(6), pages 1-9, May.
    5. Rong Su & Le Cai & Wenlong Cui & Jianhui He & Dingyun You & Allison Golden, 2016. "Multilevel Analysis of Socioeconomic Determinants on Diabetes Prevalence, Awareness, Treatment and Self-Management in Ethnic Minorities of Yunnan Province, China," IJERPH, MDPI, vol. 13(8), pages 1-12, July.
    6. Haiying Gong & Lize Pa & Ke Wang & Hebuli Mu & Fen Dong & Shengjiang Ya & Guodong Xu & Ning Tao & Li Pan & Bin Wang & Guangliang Shan, 2015. "Prevalence of Diabetes and Associated Factors in the Uyghur and Han Population in Xinjiang, China," IJERPH, MDPI, vol. 12(10), pages 1-11, October.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:12:y:2015:i:7:p:8023-8033:d:52517. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.