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Successful Nicotine Intake in Medical Assisted Use of E-Cigarettes: A Pilot Study

Author

Listed:
  • Roberta Pacifici

    (Drug Abuse and Doping Unit, Department of Therapeutic Research and Medicines Evaluation National Institute of Health, Roma 00161, Italy)

  • Simona Pichini

    (Drug Abuse and Doping Unit, Department of Therapeutic Research and Medicines Evaluation National Institute of Health, Roma 00161, Italy)

  • Silvia Graziano

    (Drug Abuse and Doping Unit, Department of Therapeutic Research and Medicines Evaluation National Institute of Health, Roma 00161, Italy)

  • Manuela Pellegrini

    (Drug Abuse and Doping Unit, Department of Therapeutic Research and Medicines Evaluation National Institute of Health, Roma 00161, Italy)

  • Giuseppina Massaro

    (Ospedale San Giovanni Bosco, ASL TO2 Torino 10154, Italy)

  • Fabio Beatrice

    (Ospedale San Giovanni Bosco, ASL TO2 Torino 10154, Italy)

Abstract

The electronic cigarette (e-cig) has gained popularity as an aid in smoking cessation programs mainly because it maintains the gestures and rituals of tobacco smoking. However, it has been shown in inexperienced e-cig users that ineffective nicotine delivery can cause tobacco craving that could be responsible for unsuccessful smoking reduction/cessation. Moreover, the incorrect use of an e-cig could also led to potential nicotine overdosage and intoxication. Medically assisted training on the proper use of an e-cig plus behavioral support for tobacco dependence could be a pivotal step in avoiding both issues. We performed an eight-month pilot study of adult smokers who started e-cig use after receiving a multi-component medically assisted training program with monitoring of nicotine intake as a biomarker of correct e-cig use. Participants were tested during follow-up for breath carbon monoxide (CO), plasma cotinine and trans -3’-hydroxycotinine, and number of tobacco cigarettes smoked. At the end of the first, fourth, and eighth month of follow-up, 91.1, 73.5, and 76.5% of participants respectively were e-cig users (‘only e-cig’ and ‘dual users’). They showed no significant variation in plasma cotinine and trans -3’-hydroxycotinine with respect to the start of the study when they smoked only tobacco cigarettes, but a significant reduction in breath CO. The proposed medically assisted training program of e-cig use led to a successful nicotine intake, lack of typical cigarette craving and overdosage symptoms and a significant decrease in the biomarker of cigarette combustion products.

Suggested Citation

  • Roberta Pacifici & Simona Pichini & Silvia Graziano & Manuela Pellegrini & Giuseppina Massaro & Fabio Beatrice, 2015. "Successful Nicotine Intake in Medical Assisted Use of E-Cigarettes: A Pilot Study," IJERPH, MDPI, vol. 12(7), pages 1-9, July.
  • Handle: RePEc:gam:jijerp:v:12:y:2015:i:7:p:7638-7646:d:52235
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    References listed on IDEAS

    as
    1. Karolien Adriaens & Dinska Van Gucht & Paul Declerck & Frank Baeyens, 2014. "Effectiveness of the Electronic Cigarette: An Eight-Week Flemish Study with Six-Month Follow-up on Smoking Reduction, Craving and Experienced Benefits and Complaints," IJERPH, MDPI, vol. 11(11), pages 1-29, October.
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    Cited by:

    1. Shirley A. James & Ellen M. Meier & Theodore L. Wagener & Katherine M. Smith & Barbara R. Neas & Laura A. Beebe, 2016. "E-Cigarettes for Immediate Smoking Substitution in Women Diagnosed with Cervical Dysplasia and Associated Disorders," IJERPH, MDPI, vol. 13(3), pages 1-11, March.

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