Author
Listed:
- Agnes G. Oomen
(National Institute for Public Health and the Environment (RIVM), PO Box 1, Bilthoven 3720, The Netherlands)
- Eric A. J. Bleeker
(National Institute for Public Health and the Environment (RIVM), PO Box 1, Bilthoven 3720, The Netherlands)
- Peter M. J. Bos
(National Institute for Public Health and the Environment (RIVM), PO Box 1, Bilthoven 3720, The Netherlands)
- Fleur Van Broekhuizen
(National Institute for Public Health and the Environment (RIVM), PO Box 1, Bilthoven 3720, The Netherlands)
- Stefania Gottardo
(Joint Research Centre, European Commission, Via E. Fermi 2749, Ispra 21027, Italy)
- Monique Groenewold
(National Institute for Public Health and the Environment (RIVM), PO Box 1, Bilthoven 3720, The Netherlands)
- Danail Hristozov
(Department of Environmental Sciences, Informatics and Statistics, University Ca’ Foscari of Venice, Vegapark, Via delle Industrie 21/8, Marghera 30175, Venice, Italy)
- Kerstin Hund-Rinke
(Fraunhofer Institute for Molecular Biology and Applied Ecology, Auf dem Aberg 1, Schmallenberg 57392, Germany)
- Muhammad-Adeel Irfan
(BASF SE, GB/TB-Z470, Ludwigshafen 67056, Germany)
- Antonio Marcomini
(Department of Environmental Sciences, Informatics and Statistics, University Ca’ Foscari of Venice, Vegapark, Via delle Industrie 21/8, Marghera 30175, Venice, Italy)
- Willie J. G. M. Peijnenburg
(National Institute for Public Health and the Environment (RIVM), PO Box 1, Bilthoven 3720, The Netherlands
Centre for Environmental Sciences, University Leiden, PO Box 9518, Leiden 2300, The Netherlands)
- Kirsten Rasmussen
(Joint Research Centre, European Commission, Via E. Fermi 2749, Ispra 21027, Italy)
- Araceli Sánchez Jiménez
(Centre for Human Exposure Science (CHES), Institute of Occupational Medicine (IOM), Edinburgh EH14 4AP, UK)
- Janeck J. Scott-Fordsmand
(Dept Bioscience, Aarhus University, Vejlsøvej 25, PO Box 314, Silkeborg 8600, Denmark)
- Martie Van Tongeren
(Centre for Human Exposure Science (CHES), Institute of Occupational Medicine (IOM), Edinburgh EH14 4AP, UK)
- Karin Wiench
(BASF SE, GB/TB-Z470, Ludwigshafen 67056, Germany)
- Wendel Wohlleben
(BASF SE, GB/TB-Z470, Ludwigshafen 67056, Germany)
- Robert Landsiedel
(BASF SE, GB/TB-Z470, Ludwigshafen 67056, Germany)
Abstract
Physicochemical properties of chemicals affect their exposure, toxicokinetics/fate and hazard, and for nanomaterials, the variation of these properties results in a wide variety of materials with potentially different risks. To limit the amount of testing for risk assessment, the information gathering process for nanomaterials needs to be efficient. At the same time, sufficient information to assess the safety of human health and the environment should be available for each nanomaterial. Grouping and read-across approaches can be utilised to meet these goals. This article presents different possible applications of grouping and read-across for nanomaterials within the broader perspective of the MARINA Risk Assessment Strategy (RAS), as developed in the EU FP7 project MARINA. Firstly, nanomaterials can be grouped based on limited variation in physicochemical properties to subsequently design an efficient testing strategy that covers the entire group. Secondly, knowledge about exposure, toxicokinetics/fate or hazard, for example via properties such as dissolution rate, aspect ratio, chemical (non-)activity, can be used to organise similar materials in generic groups to frame issues that need further attention, or potentially to read-across. Thirdly, when data related to specific endpoints is required, read-across can be considered, using data from a source material for the target nanomaterial. Read-across could be based on a scientifically sound justification that exposure, distribution to the target (fate/toxicokinetics) and hazard of the target material are similar to, or less than, the source material. These grouping and read-across approaches pave the way for better use of available information on nanomaterials and are flexible enough to allow future adaptations related to scientific developments.
Suggested Citation
Agnes G. Oomen & Eric A. J. Bleeker & Peter M. J. Bos & Fleur Van Broekhuizen & Stefania Gottardo & Monique Groenewold & Danail Hristozov & Kerstin Hund-Rinke & Muhammad-Adeel Irfan & Antonio Marcomin, 2015.
"Grouping and Read-Across Approaches for Risk Assessment of Nanomaterials,"
IJERPH, MDPI, vol. 12(10), pages 1-20, October.
Handle:
RePEc:gam:jijerp:v:12:y:2015:i:10:p:13415-13434:d:57776
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Cited by:
- Merve Ozkaleli & Ayca Erdem, 2018.
"Biotoxicity of TiO 2 Nanoparticles on Raphidocelis subcapitata Microalgae Exemplified by Membrane Deformation,"
IJERPH, MDPI, vol. 15(3), pages 1-12, February.
- Mónica J. B. Amorim, 2016.
"The Daunting Challenge of Ensuring Sustainable Development of Nanomaterials,"
IJERPH, MDPI, vol. 13(2), pages 1-3, February.
- David M. Metzler & Ayca Erdem & Chin Pao Huang, 2018.
"Influence of Algae Age and Population on the Response to TiO 2 Nanoparticles,"
IJERPH, MDPI, vol. 15(4), pages 1-16, March.
- Peter M. J. Bos & Stefania Gottardo & Janeck J. Scott-Fordsmand & Martie Van Tongeren & Elena Semenzin & Teresa F. Fernandes & Danail Hristozov & Kerstin Hund-Rinke & Neil Hunt & Muhammad-Adeel Irfan , 2015.
"The MARINA Risk Assessment Strategy: A Flexible Strategy for Efficient Information Collection and Risk Assessment of Nanomaterials,"
IJERPH, MDPI, vol. 12(12), pages 1-15, November.
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