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First Year Growth in Relation to Prenatal Exposure to Endocrine Disruptors — A Dutch Prospective Cohort Study

Author

Listed:
  • Marijke De Cock

    (Section Health and Life Sciences, Faculty of Earth and Life Sciences, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands)

  • Michiel R. De Boer

    (Section Health Sciences, Faculty of Earth and Life Sciences, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands)

  • Marja Lamoree

    (Institute for Environmental Studies, Faculty of Earth and Life Sciences, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands)

  • Juliette Legler

    (Institute for Environmental Studies, Faculty of Earth and Life Sciences, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands)

  • Margot Van de Bor

    (Section Health and Life Sciences, Faculty of Earth and Life Sciences, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands)

Abstract

Growth in the first year of life may already be predictive of obesity later in childhood. The objective was to assess the association between prenatal exposure to various endocrine disrupting chemicals (EDCs) and child growth during the first year. Dichloro-diphenyldichloroethylene (DDE), mono(2-ethyl-5-carboxypentyl)phthalate (MECPP), mono(2-ethyl-5-hydroxyhexyl)phthalate (MEHHP), mono(2-ethyl-5-oxohexyl)phthalate (MEOHP), polychlorinated biphenyl-153, perfluorooctanesulfonic acid, and perfluoro-octanoic acid were measured in cord plasma or breast milk. Data on weight, length, and head circumference (HC) until 11 months after birth was obtained from 89 mother-child pairs. Mixed models were composed for each health outcome and exposure in quartiles. For MEOHP, boys in quartile 1 had a higher BMI than higher exposed boys ( p = 0.029). High DDE exposure was associated with low BMI over time in boys (0.8 kg/m 2 difference at 11 m). Boys with high MECPP exposure had a greater HC (1.0 cm difference at 11 m) than other boys ( p = 0.047), as did girls in the second quartile of MEHHP ( p = 0.018) and DDE ( p < 0.001) exposure. In conclusion, exposure to phthalates and DDE was associated with BMI as well as with HC during the first year after birth. These results should be interpreted with caution though, due to the limited sample size.

Suggested Citation

  • Marijke De Cock & Michiel R. De Boer & Marja Lamoree & Juliette Legler & Margot Van de Bor, 2014. "First Year Growth in Relation to Prenatal Exposure to Endocrine Disruptors — A Dutch Prospective Cohort Study," IJERPH, MDPI, vol. 11(7), pages 1-21, July.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:7:p:7001-7021:d:38023
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    Citations

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    Cited by:

    1. Ilona Quaak & Marijke De Cock & Michiel De Boer & Marja Lamoree & Pim Leonards & Margot Van de Bor, 2016. "Prenatal Exposure to Perfluoroalkyl Substances and Behavioral Development in Children," IJERPH, MDPI, vol. 13(5), pages 1-20, May.
    2. Ye’elah E. Berman & Dorota A. Doherty & Katharina M. Main & Hanne Frederiksen & Martha Hickey & Jeffrey A. Keelan & John P. Newnham & Roger J. Hart, 2021. "Associations between Prenatal Exposure to Phthalates and Timing of Menarche and Growth and Adiposity into Adulthood: A Twenty-Years Birth Cohort Study," IJERPH, MDPI, vol. 18(9), pages 1-20, April.
    3. Eva Govarts & Sylvie Remy & Liesbeth Bruckers & Elly Den Hond & Isabelle Sioen & Vera Nelen & Willy Baeyens & Tim S Nawrot & Ilse Loots & Nick Van Larebeke & Greet Schoeters, 2016. "Combined Effects of Prenatal Exposures to Environmental Chemicals on Birth Weight," IJERPH, MDPI, vol. 13(5), pages 1-19, May.

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