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Association of Uric Acid with Metabolic Syndrome in Men, Premenopausal Women and Postmenopausal Women

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  • Yongqiang Li

    (Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China)

  • Shanying Chen

    (Department of Nephrology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China)

  • Xiaofei Shao

    (Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China)

  • Jia Guo

    (Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China)

  • Xinyu Liu

    (Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China)

  • Aiqun Liu

    (Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China)

  • Ying Zhang

    (Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China)

  • Honglei Wang

    (Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China)

  • Bin Li

    (Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China)

  • Kangping Deng

    (Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China)

  • Qin Liu

    (Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China)

  • Harry Holthöfer

    (National Centre for Sensor Research/BioAnalytical Sciences, Dublin City University, Dublin 9, Ireland)

  • Hequn Zou

    (Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China)

Abstract

Objective : To explore the relationship between serum uric acid (SUA) and metabolic syndrome (MS) in men, premenopausal women and postmenopausal women. Methods : A cross-sectional study was conducted in 1,834 community-based Southern Chinese participants from June to October 2012. Sex-specific SUA quartiles were used as follows: <345, 345–<400, 400–<468, ≥468 µmol/L in males; and <248, 248–<288, 288–<328, ≥328 µmol/L in females. MS was defined by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) Criteria. The association between SUA and MS was then analyzed using the STATA software. Results : The odds ratio (OR) for having MS in the highest versus lowest quartiles of SUA levels was 2.46 (95% confidence interval [CI], 1.39 to 4.34, p = 0.002) in men after adjusting for age, sex, history of coronary heart disease, history of stroke, current current smoking, current alcohol use, physical inactivity, education status, and BMI. Further adjusting for above confounders, hypertension and diabetes, the OR for having MS in the highest versus lowest quartiles of SUA was 3.06 (95% CI, 1.64 to 5.70, p < 0.001). The OR for having MS in the highest versus lowest quartiles of SUA was 3.45 (95% CI, 1.38 to 8.64, p = 0.008) and 1.98 (95% CI, 1.16 to 3.37, p = 0.08) in premenopausal women and postmenopausal women after adjusting for age, sex, history of coronary heart disease, history of stroke, current smoking, current alcohol use, physical inactivity, education status, and BMI. Further adjusting for above confounders, hypertension and diabetes, the OR for having MS in the highest versus lowest quartiles of SUA was 3.42 (95% CI, 1.15 to 10.18, p = 0.03) and 1.87 (95% CI, 1.05 to 3.33, p = 0.03) in premenopausal women and postmenopausal women. Conclusions : Higher SUA levels are positively associated with the presence of MS in males and females. Higher SUA levels had a higher risk of having MS in premenopausal women than in postmenopausal women.

Suggested Citation

  • Yongqiang Li & Shanying Chen & Xiaofei Shao & Jia Guo & Xinyu Liu & Aiqun Liu & Ying Zhang & Honglei Wang & Bin Li & Kangping Deng & Qin Liu & Harry Holthöfer & Hequn Zou, 2014. "Association of Uric Acid with Metabolic Syndrome in Men, Premenopausal Women and Postmenopausal Women," IJERPH, MDPI, vol. 11(3), pages 1-12, March.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:3:p:2899-2910:d:33866
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    References listed on IDEAS

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    1. Yongqiang Li & Liqin Zhao & Youming Chen & Aiqun Liu & Xinyu Liu & Xiaofei Shao & Ying Zhang & Honglei Wang & Xiaohong Wang & Bin Li & Kangping Deng & Qin Liu & Harry Holthöfer & Hequn Zou, 2013. "Association between Metabolic Syndrome and Chronic Kidney Disease in Perimenopausal Women," IJERPH, MDPI, vol. 10(9), pages 1-11, August.
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    Cited by:

    1. Michalina Lubawy & Dorota Formanowicz, 2023. "High-Fructose Diet–Induced Hyperuricemia Accompanying Metabolic Syndrome–Mechanisms and Dietary Therapy Proposals," IJERPH, MDPI, vol. 20(4), pages 1-17, February.

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