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Arsenic-Induced Genotoxicity and Genetic Susceptibility to Arsenic-Related Pathologies

Author

Listed:
  • Francesca Faita

    (Institute of Clinical Physiology, CNR, via Moruzzi 1, Pisa 56124, Italy)

  • Liliana Cori

    (Institute of Clinical Physiology, CNR, via Moruzzi 1, Pisa 56124, Italy)

  • Fabrizio Bianchi

    (Institute of Clinical Physiology, CNR, via Moruzzi 1, Pisa 56124, Italy)

  • Maria Grazia Andreassi

    (Institute of Clinical Physiology, CNR, via Moruzzi 1, Pisa 56124, Italy)

Abstract

The arsenic (As) exposure represents an important problem in many parts of the World. Indeed, it is estimated that over 100 million individuals are exposed to arsenic, mainly through a contamination of groundwaters. Chronic exposure to As is associated with adverse effects on human health such as cancers, cardiovascular diseases, neurological diseases and the rate of morbidity and mortality in populations exposed is alarming. The purpose of this review is to summarize the genotoxic effects of As in the cells as well as to discuss the importance of signaling and repair of arsenic-induced DNA damage. The current knowledge of specific polymorphisms in candidate genes that confer susceptibility to arsenic exposure is also reviewed. We also discuss the perspectives offered by the determination of biological markers of early effect on health, incorporating genetic polymorphisms, with biomarkers for exposure to better evaluate exposure-response clinical relationships as well as to develop novel preventative strategies for arsenic- health effects.

Suggested Citation

  • Francesca Faita & Liliana Cori & Fabrizio Bianchi & Maria Grazia Andreassi, 2013. "Arsenic-Induced Genotoxicity and Genetic Susceptibility to Arsenic-Related Pathologies," IJERPH, MDPI, vol. 10(4), pages 1-20, April.
    • Handle: RePEc:gam:jijerp:v:10:y:2013:i:4:p:1527-1546:d:24961
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    Cited by:

    1. Márcia Cristina da Silva Faria & Rodrigo de Carvalho Hott & Maicon Junior dos Santos & Mayra Soares Santos & Thainá Gusmão Andrade & Cleide Aparecida Bomfeti & Bruno Alves Rocha & Fernando Barbosa & J, 2023. "Arsenic in Mining Areas: Environmental Contamination Routes," IJERPH, MDPI, vol. 20(5), pages 1-17, February.
    2. Ghulam Abbas & Behzad Murtaza & Irshad Bibi & Muhammad Shahid & Nabeel Khan Niazi & Muhammad Imran Khan & Muhammad Amjad & Munawar Hussain & Natasha, 2018. "Arsenic Uptake, Toxicity, Detoxification, and Speciation in Plants: Physiological, Biochemical, and Molecular Aspects," IJERPH, MDPI, vol. 15(1), pages 1-45, January.

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