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CoviRx: A User-Friendly Interface for Systematic Down-Selection of Repurposed Drug Candidates for COVID-19

Author

Listed:
  • Hardik A. Jain

    (Birla Institute of Technology and Science, Department of Electrical and Electronics Engineering, Pilani 333031, Rajasthan, India)

  • Vinti Agarwal

    (Birla Institute of Technology and Science, Department of Computer Science and Information Systems, Pilani 333031, Rajasthan, India)

  • Chaarvi Bansal

    (Birla Institute of Technology and Science, Department of Computer Science and Information Systems, Pilani 333031, Rajasthan, India
    School of Mathematics and Statistics, University of New South Wales, Sydney, NSW 1466, Australia)

  • Anupama Kumar

    (Commonwealth Scientific and Industrial Research Organisation, Land and Water, Waite Campus, Urrbrae, SA 5064, Australia)

  • Faheem

    (Birla Institute of Technology and Science, Department of Pharmacy, Pilani 333031, Rajasthan, India
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA)

  • Muzaffar-Ur-Rehman Mohammed

    (Birla Institute of Technology and Science, Department of Pharmacy, Pilani 333031, Rajasthan, India)

  • Sankaranarayanan Murugesan

    (Birla Institute of Technology and Science, Department of Pharmacy, Pilani 333031, Rajasthan, India)

  • Moana M. Simpson

    (Compounds Australia, Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD 4111, Australia)

  • Avinash V. Karpe

    (Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia
    Commonwealth Scientific and Industrial Research Organisation, Land and Water, Dutton Park, QLD 4102, Australia)

  • Rohitash Chandra

    (School of Mathematics and Statistics, University of New South Wales, Sydney, NSW 1466, Australia)

  • Christopher A. MacRaild

    (Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3800, Australia)

  • Ian K. Styles

    (Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3800, Australia)

  • Amanda L. Peterson

    (Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3800, Australia
    Bio21 Institute, University of Melbourne, Parkville, VIC 3052, Australia)

  • Matthew A. Cooper

    (Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia)

  • Carl M. J. Kirkpatrick

    (Centre for Medicine Use and Safety, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia)

  • Rohan M. Shah

    (Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia)

  • Enzo A. Palombo

    (Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia)

  • Natalie L. Trevaskis

    (Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3800, Australia)

  • Darren J. Creek

    (Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3800, Australia)

  • Seshadri S. Vasan

    (Commonwealth Scientific and Industrial Research Organisation, Australian Centre for Disease Preparedness, Geelong, VIC 3220, Australia
    Department of Health, 189 Royal Street, East Perth, WA 6004, Australia
    Department of Health Sciences, University of York, York YO10 5DD, UK)

Abstract

Although various vaccines are now commercially available, they have not been able to stop the spread of COVID-19 infection completely. An excellent strategy to get safe, effective, and affordable COVID-19 treatments quickly is to repurpose drugs that are already approved for other diseases. The process of developing an accurate and standardized drug repurposing dataset requires considerable resources and expertise due to numerous commercially available drugs that could be potentially used to address the SARS-CoV-2 infection. To address this bottleneck, we created the CoviRx.org platform. CoviRx is a user-friendly interface that allows analysis and filtering of large quantities of data, which is onerous to curate manually for COVID-19 drug repurposing. Through CoviRx, the curated data have been made open source to help combat the ongoing pandemic and encourage users to submit their findings on the drugs they have evaluated, in a uniform format that can be validated and checked for integrity by authenticated volunteers. This article discusses the various features of CoviRx, its design principles, and how its functionality is independent of the data it displays. Thus, in the future, this platform can be extended to include any other disease beyond COVID-19.

Suggested Citation

  • Hardik A. Jain & Vinti Agarwal & Chaarvi Bansal & Anupama Kumar & Faheem & Muzaffar-Ur-Rehman Mohammed & Sankaranarayanan Murugesan & Moana M. Simpson & Avinash V. Karpe & Rohitash Chandra & Christoph, 2022. "CoviRx: A User-Friendly Interface for Systematic Down-Selection of Repurposed Drug Candidates for COVID-19," Data, MDPI, vol. 7(11), pages 1-19, November.
    • Handle: RePEc:gam:jdataj:v:7:y:2022:i:11:p:164-:d:976387
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    References listed on IDEAS

    as
    1. Melitz, Jacques & Toubal, Farid, 2014. "Native language, spoken language, translation and trade," Journal of International Economics, Elsevier, vol. 93(2), pages 351-363.
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