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The Effects of the Fungicide Myclobutanil on Soil Enzyme Activity

Author

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  • Diana Larisa Roman

    (Department of Biology-Chemistry, Faculty of Chemistry, Biology, Geography, West University of Timisoara, 16 Pestalozzi, 300115 Timisoara, Romania
    Advanced Environmental Research Laboratories (AERL), 4 Oituz, 300086 Timisoara, Romania
    These authors contributed equally to this work.)

  • Mariana Adina Matica

    (Department of Chemistry-Biology, Institute for Advanced Environmental Research (ICAM), West University of Timisoara, Oituz 4C, 300086 Timisoara, Romania
    These authors contributed equally to this work.)

  • Alecu Ciorsac

    (Department of Physical Education and Sport, University Politehnica Timișoara, 300006 Timișoara, Romania)

  • Bianca Vanesa Boros

    (Department of Biology-Chemistry, Faculty of Chemistry, Biology, Geography, West University of Timisoara, 16 Pestalozzi, 300115 Timisoara, Romania
    Advanced Environmental Research Laboratories (AERL), 4 Oituz, 300086 Timisoara, Romania)

  • Adriana Isvoran

    (Department of Biology-Chemistry, Faculty of Chemistry, Biology, Geography, West University of Timisoara, 16 Pestalozzi, 300115 Timisoara, Romania
    Advanced Environmental Research Laboratories (AERL), 4 Oituz, 300086 Timisoara, Romania)

Abstract

(1) Background: The use of pesticides, although needed to protect crops and increase production, represents an environmental and human health issue. Therefore, measures must be taken in order to develop a better understanding of the risks involved in the overuse of these compounds. Myclobutanil is a chiral triazole fungicide widely used for the protection of crops against fungal diseases. Published data have shown that, although effective in preventing fungal infections, high doses of myclobutanil can affect the soil environment. The aim of this study was to evaluate the effect of different doses of myclobutanil on soil enzyme activity, as well as the possible specificity of the interactions of the two stereoisomers of myclobutanil with these enzymes. (2) Methods: A combination of experimental and computational approaches was considered. An experimental method was applied in order to assess the effect of different doses of myclobutanil on the activity of dehydrogenase, phosphatase, catalase, urease and protease. The computational approach was based on the molecular docking of the two enantiomers of myclobutanil with the above-mentioned enzymes to assess the possible enantioselectivity of the interactions. (3) Results: High doses of myclobutanil significantly affected the enzymatic activity of dehydrogenase and led to a slight increase in the activity of catalase. Molecular docking data showed that both enantiomers of myclobutanil were able to bind to the active sites of dehydrogenase, phsosphatase and protease, with higher interacting energies observed for (S) -myclobutanil, the enantiomer known to be less active against target organisms but have a higher toxicity against non-target organisms. (4) Conclusions: The results of our study confirm the need to implement better management practices regarding the use of myclobutanil (and of pesticides in general) by using the enantiomer that is most effective on target organisms and less toxic to non-target organisms.

Suggested Citation

  • Diana Larisa Roman & Mariana Adina Matica & Alecu Ciorsac & Bianca Vanesa Boros & Adriana Isvoran, 2023. "The Effects of the Fungicide Myclobutanil on Soil Enzyme Activity," Agriculture, MDPI, vol. 13(10), pages 1-19, October.
    • Handle: RePEc:gam:jagris:v:13:y:2023:i:10:p:1956-:d:1254871
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    References listed on IDEAS

    as
    1. Diana Larisa Roman & Denisa Ioana Voiculescu & Madalina Filip & Vasile Ostafe & Adriana Isvoran, 2021. "Effects of Triazole Fungicides on Soil Microbiota and on the Activities of Enzymes Found in Soil: A Review," Agriculture, MDPI, vol. 11(9), pages 1-18, September.
    2. Marioara Nicoleta Caraba & Diana Larisa Roman & Ion Valeriu Caraba & Adriana Isvoran, 2023. "Assessment of the Effects of the Herbicide Aclonifen and Its Soil Metabolites on Soil and Aquatic Environments," Agriculture, MDPI, vol. 13(6), pages 1-16, June.
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    Cited by:

    1. Diana-Larisa Roman & Mariana Adina Matica & Bianca-Vanesa Boros & Constantina-Bianca Vulpe & Adriana Isvoran, 2024. "Evaluation of the Impact of Flutriafol on Soil Culturable Microorganisms and on Soil Enzymes Activity," Agriculture, MDPI, vol. 14(9), pages 1-22, August.

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