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Isolation-by-distance-and-time in a stepping-stone model

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  • Duforet-Frebourg, Nicolas
  • Slatkin, Montgomery

Abstract

With the great advances in ancient DNA extraction, genetic data are now obtained from geographically separated individuals from both present and past. However, population genetics theory about the joint effect of space and time has not been thoroughly studied. Based on the classical stepping-stone model, we develop the theory of Isolation by distance and time. We derive the correlation of allele frequencies between demes in the case where ancient samples are present, and investigate the impact of edge effects with forward-in-time simulations. We also derive results about coalescent times in circular and toroidal models. As one of the most common ways to investigate population structure is principal components analysis (PCA), we evaluate the impact of our theory on PCA plots. Our results demonstrate that time between samples is an important factor. Ancient samples tend to be drawn to the center of a PCA plot.

Suggested Citation

  • Duforet-Frebourg, Nicolas & Slatkin, Montgomery, 2016. "Isolation-by-distance-and-time in a stepping-stone model," Theoretical Population Biology, Elsevier, vol. 108(C), pages 24-35.
    • Handle: RePEc:eee:thpobi:v:108:y:2016:i:c:p:24-35
    DOI: 10.1016/j.tpb.2015.11.003
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    References listed on IDEAS

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    Cited by:

    1. Estavoyer, Maxime & François, Olivier, 2022. "Theoretical analysis of principal components in an umbrella model of intraspecific evolution," Theoretical Population Biology, Elsevier, vol. 148(C), pages 11-21.

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