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The social management of biomedical novelty: Facilitating translation in regenerative medicine

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  • Gardner, John
  • Webster, Andrew

Abstract

Regenerative medicine (RM) is championed as a potential source of curative treatments for a variety of illnesses, and as a generator of economic wealth and prosperity. Alongside this optimism, however, is a sense of concern that the translation of basic science into useful RM therapies will be laboriously slow due to a range of challenges relating to live tissue handling and manufacturing, regulation, reimbursement and commissioning, and clinical adoption. This paper explores the attempts of stakeholders to overcome these innovation challenges and thus facilitate the emergence of useful RM therapies. The paper uses the notion of innovation niches as an analytical frame. Innovation niches are collectively constructed socio-technical spaces in which a novel technology can be tested and further developed, with the intention of enabling wider adoption. Drawing on primary and secondary data, we explore the motivation for, and the attempted construction of, niches in three domains which are central to the adoption of innovative technologies: the regulatory, the health economic, and the clinical. We illustrate that these niches are collectively constructed via both formal and informal initiatives, and we argue that they reflect wider socio-political trends in the social management of biomedical novelty.

Suggested Citation

  • Gardner, John & Webster, Andrew, 2016. "The social management of biomedical novelty: Facilitating translation in regenerative medicine," Social Science & Medicine, Elsevier, vol. 156(C), pages 90-97.
    • Handle: RePEc:eee:socmed:v:156:y:2016:i:c:p:90-97
    DOI: 10.1016/j.socscimed.2016.03.025
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    References listed on IDEAS

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    1. Ulucanlar, S. & Faulkner, A. & Peirce, S. & Elwyn, G., 2013. "Technology identity: The role of sociotechnical representations in the adoption of medical devices," Social Science & Medicine, Elsevier, vol. 98(C), pages 95-105.
    2. Salter, Brian & Salter, Charlotte, 2013. "Bioethical ambition, political opportunity and the European governance of patenting: The case of human embryonic stem cell science," Social Science & Medicine, Elsevier, vol. 98(C), pages 286-292.
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    4. Geels, Frank W., 2004. "From sectoral systems of innovation to socio-technical systems: Insights about dynamics and change from sociology and institutional theory," Research Policy, Elsevier, vol. 33(6-7), pages 897-920, September.
    5. Rod Coombs & Mark Harvey & Bruce S. Tether, 2003. "Analysing distributed processes of provision and innovation," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 12(6), pages 1125-1155, December.
    6. Hogarth, Stuart, 2015. "Neoliberal technocracy: Explaining how and why the US Food and Drug Administration has championed pharmacogenomics," Social Science & Medicine, Elsevier, vol. 131(C), pages 255-262.
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    Cited by:

    1. Gardner, John & Higham, Ruchi & Faulkner, Alex & Webster, Andrew, 2017. "Promissory identities: Sociotechnical representations & innovation in regenerative medicine," Social Science & Medicine, Elsevier, vol. 174(C), pages 70-78.
    2. Erik Aarden & Luca Marelli & Alessandro Blasimme, 2021. "The translational lag narrative in policy discourse in the United States and the European Union: a comparative study," Palgrave Communications, Palgrave Macmillan, vol. 8(1), pages 1-9, December.
    3. Hogarth, Stuart & Löblová, Olga, 2022. "Regulatory niches: Diagnostic reform as a process of fragmented expansion. Evidence from the UK 1990–2018," Social Science & Medicine, Elsevier, vol. 304(C).
    4. Massaro, Sebastiano & Lorenzoni, Gianni, 2021. "Nanomedicine: a socio-technical system," Technological Forecasting and Social Change, Elsevier, vol. 173(C).
    5. Alberto Bezama & Carlo Ingrao & Sinéad O’Keeffe & Daniela Thrän, 2019. "Resources, Collaborators, and Neighbors: The Three-Pronged Challenge in the Implementation of Bioeconomy Regions," Sustainability, MDPI, vol. 11(24), pages 1-18, December.
    6. James F. Stark, 2018. "Perspectives on human regeneration," Palgrave Communications, Palgrave Macmillan, vol. 4(1), pages 1-6, December.

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