IDEAS home Printed from https://ideas.repec.org/a/eee/rensus/v189y2024ipas1364032123007633.html
   My bibliography  Save this article

Advances in the vanillin synthesis and biotransformation: A review

Author

Listed:
  • Xu, Lingxia
  • Liaqat, Fakhra
  • Sun, Jianzhong
  • Khazi, Mahammed Ilyas
  • Xie, Rongrong
  • Zhu, Daochen

Abstract

Vanillin is one of the world's most extensively used flavoring compounds. Plant-based vanillin can no longer meet the annual global demand for bio-vanillin, thus chemical synthesis is commonly used to manufacture vanillin. Considering the environmental impact of chemical synthesis, the possibility of utilizing microbial genetic and metabolic engineering to transform renewable biomass-based substrates into vanillin offers a promising alternative to produce commercially viable bio-vanillin. However, research on this topic is still in its early stages, and there is still a need for an effective and dynamic method to achieve high vanillin productivity. This review aims to comprehensively discuss recent advances in microbial vanillin production through genetic and metabolic engineering strategies. Molecular mechanisms of vanillin toxicity in microbes and strategies for improving vanillin tolerance are also discussed. Finally, a comprehensive literature analysis explored the feasibility of new potential and sustainable methods for vanillin production from lignin on an industrial scale. However, the high cost of raw materials pretreatment, low yields, and complex downstream processes continue to be the primary factors hindering its industrialization. This review identifies potential areas for future research and optimization, emphasizing the importance of exploring eco-friendly and renewable approaches. Overall, the review provides valuable information for future research directions, industry professionals, and policymakers interested in vanillin synthesis, offering an overview of the latest advancements and potential for sustainable vanillin production.

Suggested Citation

  • Xu, Lingxia & Liaqat, Fakhra & Sun, Jianzhong & Khazi, Mahammed Ilyas & Xie, Rongrong & Zhu, Daochen, 2024. "Advances in the vanillin synthesis and biotransformation: A review," Renewable and Sustainable Energy Reviews, Elsevier, vol. 189(PA).
    • Handle: RePEc:eee:rensus:v:189:y:2024:i:pa:s1364032123007633
    DOI: 10.1016/j.rser.2023.113905
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S1364032123007633
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.rser.2023.113905?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Zhi-Hua Liu & Naijia Hao & Yun-Yan Wang & Chang Dou & Furong Lin & Rongchun Shen & Renata Bura & David B. Hodge & Bruce E. Dale & Arthur J. Ragauskas & Bin Yang & Joshua S. Yuan, 2021. "Transforming biorefinery designs with ‘Plug-In Processes of Lignin’ to enable economic waste valorization," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Nethaji J. Gallage & Esben H. Hansen & Rubini Kannangara & Carl Erik Olsen & Mohammed Saddik Motawia & Kirsten Jørgensen & Inger Holme & Kim Hebelstrup & Michel Grisoni & Birger Lindberg Møller, 2014. "Vanillin formation from ferulic acid in Vanilla planifolia is catalysed by a single enzyme," Nature Communications, Nature, vol. 5(1), pages 1-14, September.
    3. Zhu, Daochen & Qaria, Majjid A. & Zhu, Bin & Sun, Jianzhong & Yang, Bin, 2022. "Extremophiles and extremozymes in lignin bioprocessing," Renewable and Sustainable Energy Reviews, Elsevier, vol. 157(C).
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Sheng, Haoqiang & Huang, Xiaobin & Hu, Wenbin & Ji, Yuan & Chen, Junming & Xie, Mingyun & He, Miaoshen & Zhang, Bo & Liu, Hong, 2023. "Stability and combustion performance enhancement of ethanol/kerosene fuel by carbonized poly[cyclotriphosphazene-co-(4,4′-sulfonyldiphenol)] nanotubes via biomimetic hydrogen bonding strategy," Energy, Elsevier, vol. 282(C).
    2. Liu, Ruo-Ying & Lan, Hai-Na & Liu, Zhi-Hua & Li, Bing-Zhi & Yuan, Ying-Jin, 2024. "Microbial valorization of lignin toward coumarins: Challenges and perspectives," Renewable and Sustainable Energy Reviews, Elsevier, vol. 191(C).

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:rensus:v:189:y:2024:i:pa:s1364032123007633. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/wps/find/journaldescription.cws_home/600126/description#description .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.