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Thermodynamic considerations on the role of heat and mass transfer in biochemical causes of carcinogenesis

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  • Lucia, Umberto
  • Grisolia, Giulia
  • Ponzetto, Antonio
  • Deisboeck, Thomas S.

Abstract

Cellular homoeostasis involves a continuous interaction between the cell and its microenvironment. As such, active and passive transport of ions, nutrients, molecules and water are the basis for biochemical–physical cell life. These transport phenomena change the internal and external ionic concentrations, and, as a consequence, the cell membrane’s electric potential and the pH. In this paper we focus on the relationship between these ion transport-induced pH and membrane voltage changes to highlight their impact on carcinogenesis. The preliminary results suggest a critical role for Cl− in driving tumour transformation towards a more malignant phenotype.

Suggested Citation

  • Lucia, Umberto & Grisolia, Giulia & Ponzetto, Antonio & Deisboeck, Thomas S., 2018. "Thermodynamic considerations on the role of heat and mass transfer in biochemical causes of carcinogenesis," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 490(C), pages 1164-1170.
    • Handle: RePEc:eee:phsmap:v:490:y:2018:i:c:p:1164-1170
    DOI: 10.1016/j.physa.2017.08.075
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    Citations

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    Cited by:

    1. Lucia, Umberto & Grisolia, Giulia & Francia, Sabrina & Astori, Mariarosa, 2019. "Theoretical biophysical approach to cross-linking effects on eyes pressure," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 534(C).
    2. Guerra, A. & Rodriguez, D.J. & Montero, S. & Betancourt-Mar, J.A. & Martin, R.R. & Silva, E. & Bizzarri, M. & Cocho, G. & Mansilla, R. & Nieto-Villar, J.M., 2018. "Phase transitions in tumor growth VI: Epithelial–Mesenchymal transition," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 499(C), pages 208-215.
    3. Carlo Bianca & Marco Menale, 2019. "A Convergence Theorem for the Nonequilibrium States in the Discrete Thermostatted Kinetic Theory," Mathematics, MDPI, vol. 7(8), pages 1-13, July.
    4. Yadati, Yash & Mears, Nicholas & Chatterjee, Atanu, 2020. "Spatio-temporal characterization of thermal fluctuations in a non-turbulent Rayleigh–Bénard convection at steady state," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 547(C).

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