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Multistability and sustained oscillations in a model for protein complex formation

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  • Löb, Daniel
  • Priester, Christopher
  • Drossel, Barbara

Abstract

We investigate a model for the formation of protein complexes where each protein can occur at most once in a complex. The reaction rates for association and dissociation of proteins can be chosen independently for each reaction, without imposing detailed balance conditions. We show that this simple model can display multistability and periodic oscillations when it contains at least four different protein species. We prove that a system with three elementary species cannot be multistable.

Suggested Citation

  • Löb, Daniel & Priester, Christopher & Drossel, Barbara, 2016. "Multistability and sustained oscillations in a model for protein complex formation," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 445(C), pages 85-101.
    • Handle: RePEc:eee:phsmap:v:445:y:2016:i:c:p:85-101
    DOI: 10.1016/j.physa.2015.10.092
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    References listed on IDEAS

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    1. Matthew Thomson & Jeremy Gunawardena, 2009. "Unlimited multistability in multisite phosphorylation systems," Nature, Nature, vol. 460(7252), pages 274-277, July.
    2. Silvia D. M. Santos & James E. Ferrell, 2008. "On the cell cycle and its switches," Nature, Nature, vol. 454(7202), pages 288-289, July.
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