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Long-range cargo transport on crowded microtubules: The motor jamming mechanism

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  • Rossi, Lucas W.
  • Radtke, Paul K.
  • Goldman, Carla

Abstract

The hopping model for cargo transport by molecular motors introduced in Goldman and Sena (2009), Goldman (2010) is extended here in order to incorporate the movement of cargo–motor complexes (C–MC). Hopping processes in this context express the possibility for cargo to be exchanged between neighboring motors at a microtubule where the transport takes place. Jamming of motors is essential for cargos to execute long-range movement in this way. Results from computer simulations accompanied by a mean-field analysis of the extended model confirm our previous analytical results and suggests that an interplay between cargo hopping and the movement of the C–MC’s would control the efficiency of cargo transfer and cargo delivery in these model systems.

Suggested Citation

  • Rossi, Lucas W. & Radtke, Paul K. & Goldman, Carla, 2014. "Long-range cargo transport on crowded microtubules: The motor jamming mechanism," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 401(C), pages 319-329.
    • Handle: RePEc:eee:phsmap:v:401:y:2014:i:c:p:319-329
    DOI: 10.1016/j.physa.2014.01.041
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    References listed on IDEAS

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    1. D. Chowdhury & A. Basu & A. Garai & P. Greulich & K. Nishinari & A. Schadschneider & T. Tripathi, 2008. "Intra-cellular traffic: bio-molecular motors on filamentary tracks," The European Physical Journal B: Condensed Matter and Complex Systems, Springer;EDP Sciences, vol. 64(3), pages 593-600, August.
    2. Goldman, Carla & Sena, Elisa T., 2009. "The dynamics of cargo driven by molecular motors in the context of asymmetric simple exclusion processes," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 388(17), pages 3455-3464.
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    Cited by:

    1. López-Alamilla, N.J. & Challis, K.J. & Deaker, A.G. & Jack, M.W., 2023. "The effect of futile chemical cycles on chemical-to-mechanical energy conversion in interacting motor protein systems," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 615(C).

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