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Frequency–rank correlations of rhodopsin mutations with tuned hydropathic roughness based on self-organized criticality

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  • Phillips, J.C.

Abstract

The behavior of disease-linked mutations of membrane proteins is especially simple in rhodopsin, where they are well-studied, as they are responsible for retinitis pigmentosa, RP (retinal degeneration). Here we show that the frequency of occurrence of single RP mutations is strongly influenced by their transportational survival rates, and that this survival correlates well (82%) with a long-range, non-local hydropathic measure of the roughness of the water interfaces of ex-membrane rhodopsin based on self-organized criticality (SOC). It is speculated that this concept may be generally useful in studying survival rates of many mutated proteins.

Suggested Citation

  • Phillips, J.C., 2012. "Frequency–rank correlations of rhodopsin mutations with tuned hydropathic roughness based on self-organized criticality," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 391(22), pages 5473-5478.
    • Handle: RePEc:eee:phsmap:v:391:y:2012:i:22:p:5473-5478
    DOI: 10.1016/j.physa.2012.06.020
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    References listed on IDEAS

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    1. Moret, M.A., 2011. "Self-organized critical model for protein folding," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 390(17), pages 3055-3059.
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    Cited by:

    1. Monteiro, R.L.S. & Fontoura, J.R.A. & Carneiro, T.K.G. & Moret, M.A. & Pereira, H.B.B., 2014. "Evolution based on chromosome affinity from a network perspective," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 403(C), pages 276-283.

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