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Tomography of functional organization in protein–protein interaction network

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  • Huang, Jiun-Yan

Abstract

In recent years, after high throughput PPI data was available, studies have focused on unraveling how proteins organize their functionality from architecture of the PPI network. We examine the functional organization of a PPI network by dividing the network into layered structure around a protein according to shortest path length. We proposed an index, functional correlation, to assess the functional closeness of a specific protein with its l layer neighbors, i.e. proteins having l shortest path length from the center protein. Our results showed that functional correlation decays exponentially with the number of layers within a characteristic length lc, and it becomes uncorrelated outside such a characteristic length. A simple model based on functional unit structure was proposed to explain this exponential decay of functional correlation.

Suggested Citation

  • Huang, Jiun-Yan, 2009. "Tomography of functional organization in protein–protein interaction network," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 388(10), pages 2072-2080.
    • Handle: RePEc:eee:phsmap:v:388:y:2009:i:10:p:2072-2080
    DOI: 10.1016/j.physa.2009.01.023
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    References listed on IDEAS

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    1. Goh, K.-I. & Kahng, B. & Kim, D., 2005. "Graph theoretic analysis of protein interaction networks of eukaryotes," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 357(3), pages 501-512.
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