IDEAS home Printed from https://ideas.repec.org/a/eee/phsmap/v387y2008i22p5387-5402.html
   My bibliography  Save this article

Systematic characterization of drug release profiles from finite-sized hydrogels

Author

Listed:
  • Casault, Sébastien
  • Slater, Gary W.

Abstract

Diffusion is often used as the primary method of molecular transport in drug delivery schemes. We present a systematic investigation of the Weibull and Peppas functions as useful tools in quantifying drug release profiles. The data is obtained from 2D simulated hydrogels and diffusion is modeled using an exact enumeration scheme. We show the fitting parameters to be largely time-dependent and therefore unreliable in indicating fundamental characteristics of the underlying physical mechanism. The parameters in the Weibull function however, have a stable regime when characterizing release profiles; we propose a simple iterative test that can be used to ensure that one is in this stable regime. Also, the mechanism of diffusion is shown to be independent of obstacle density in hydrogels that are larger than their respective characteristic lengths; a homogeneous obstacle distribution can therefore be replaced by an effective viscosity.

Suggested Citation

  • Casault, Sébastien & Slater, Gary W., 2008. "Systematic characterization of drug release profiles from finite-sized hydrogels," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 387(22), pages 5387-5402.
    • Handle: RePEc:eee:phsmap:v:387:y:2008:i:22:p:5387-5402
    DOI: 10.1016/j.physa.2008.05.013
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0378437108004263
    Download Restriction: Full text for ScienceDirect subscribers only. Journal offers the option of making the article available online on Science direct for a fee of $3,000
    File URL: https://libkey.io/10.1016/j.physa.2008.05.013?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ignacio, M. & Slater, G.W., 2021. "Using fitting functions to estimate the diffusion coefficient of drug molecules in diffusion-controlled release systems," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 567(C).
    2. Singh, Kulveer & Satapathi, Soumitra & Jha, Prateek K., 2019. "“Ant-Wall” model to study drug release from excipient matrix," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 519(C), pages 98-108.
    3. Ignacio, Maxime & Chubynsky, Mykyta V. & Slater, Gary W., 2017. "Interpreting the Weibull fitting parameters for diffusion-controlled release data," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 486(C), pages 486-496.
    4. Ignacio, M. & Slater, G.W., 2022. "A Lattice Kinetic Monte Carlo method to study drug release from swelling porous delivery systems," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 603(C).

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:phsmap:v:387:y:2008:i:22:p:5387-5402. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.journals.elsevier.com/physica-a-statistical-mechpplications/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.