IDEAS home Printed from https://ideas.repec.org/a/eee/phsmap/v364y2006icp13-22.html
   My bibliography  Save this article

Long-term correlation in single calcium-activated potassium channel kinetics

Author

Listed:
  • Campos de Oliveira, R.A.
  • Barbosa, C.T.F.
  • Consoni, L.H.A.
  • Rodrigues, A.R.A.
  • Varanda, W.A.
  • Nogueira, R.A.

Abstract

Ion channels are protein molecules found in biological membranes, which can assume distinct open and closed conformational states, a phenomenon called ion channel kinetics. The transitions from one state to another are dependent on the potential energy barrier that separates them and can be controlled by the electrical field, ions and/or drugs. Both Markovian and fractal models have been used for modeling the ion channel kinetics. Ion single channel records are characterized by successive openings and closings, which are correlated in time. Here the rescaled range analysis (R/S Hurst analysis) is used to test for the occurrence of long-term correlation in the kinetics of a calcium-activated potassium channel of Leydig cells. A Hurst coefficient H=0.640±0.064 (n=5) was found for the single calcium-activated potassium channel clamped at −80mV and exposed to a free Ca2+ concentration equal to 10nM. This numerical value indicates the presence of long-term correlation (memory) in this kinetic process. However, when the R/S analysis was applied to ion channel data simulated using Markovian and fractal models, it could not account for the long-term correlation previously found in the experimental data. In summary, in this work we show that: (i) opening and closing dwell times for the single calcium-activated potassium channel of Leydig cells present long-term correlation and (ii) Markovian and fractal models, which describe well the dwell time distributions, are not adequate to describe the memory found in the kinetics of this channel.

Suggested Citation

  • Campos de Oliveira, R.A. & Barbosa, C.T.F. & Consoni, L.H.A. & Rodrigues, A.R.A. & Varanda, W.A. & Nogueira, R.A., 2006. "Long-term correlation in single calcium-activated potassium channel kinetics," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 364(C), pages 13-22.
  • Handle: RePEc:eee:phsmap:v:364:y:2006:i:c:p:13-22
    DOI: 10.1016/j.physa.2005.08.057
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0378437105008836
    Download Restriction: Full text for ScienceDirect subscribers only. Journal offers the option of making the article available online on Science direct for a fee of $3,000

    File URL: https://libkey.io/10.1016/j.physa.2005.08.057?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Félix-Martínez, G.J. & Picones, A. & Godínez-Fernández, J.R., 2024. "Short and long-range correlations in single-channel currents from inwardly rectifying K+ channels," Chaos, Solitons & Fractals, Elsevier, vol. 178(C).
    2. Borys, Przemysław & Trybek, Paulina & Dworakowska, Beata & Sekrecka-Belniak, Anna & Nurowska, Ewa & Bednarczyk, Piotr & Wawrzkiewicz-Jałowiecka, Agata, 2024. "Selectivity filter conductance, rectification and fluctuations of subdomains—How can this all relate to the value of Hurst exponent in the dwell-times of ion channels states?," Chaos, Solitons & Fractals, Elsevier, vol. 180(C).

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:phsmap:v:364:y:2006:i:c:p:13-22. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.journals.elsevier.com/physica-a-statistical-mechpplications/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.