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Short and long-range correlations in single-channel currents from inwardly rectifying K+ channels

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  • Félix-Martínez, G.J.
  • Picones, A.
  • Godínez-Fernández, J.R.

Abstract

Ion channels mediate the transport of ions through the cell membrane and are involved in key processes such as muscle contraction, nerve excitability and hormone secretion. For decades, the main focus of the standard techniques for the analysis and modeling of single-channel currents has been to characterize the gating of ionic channels by analyzing the current amplitudes and dwell-time histograms, thus neglecting the possibility that pore fluctuations (open and closed), usually considered to be stochastic noise, might contain valuable information about the functional aspects of ion channels. Based on the analysis of a deterministic model indicating that the stochastic gating of ion channels could be produced by correlated pore fluctuations, in this work, we analyzed experimental recordings of single channel currents of an inwardly rectifying K+ channel in order to demonstrate the presence of both short and long range correlations in the open and closed pore fluctuations

Suggested Citation

  • Félix-Martínez, G.J. & Picones, A. & Godínez-Fernández, J.R., 2024. "Short and long-range correlations in single-channel currents from inwardly rectifying K+ channels," Chaos, Solitons & Fractals, Elsevier, vol. 178(C).
    • Handle: RePEc:eee:chsofr:v:178:y:2024:i:c:s0960077923012353
    DOI: 10.1016/j.chaos.2023.114333
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    References listed on IDEAS

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    1. Siwy, Zuzanna & Mercik, Szymon & Weron, Karina & Ausloos, Marcel, 2001. "Application of dwell-time series in studies of long-range correlation in single channel ion transport: analysis of ion current through a big conductance locust potassium channel," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 297(1), pages 79-96.
    2. Gheorghe Acbas & Katherine A. Niessen & Edward H. Snell & A.G. Markelz, 2014. "Optical measurements of long-range protein vibrations," Nature Communications, Nature, vol. 5(1), pages 1-7, May.
    3. Katrina A. Black & Sitong He & Ruitao Jin & David M. Miller & Jani R. Bolla & Oliver B. Clarke & Paul Johnson & Monique Windley & Christopher J. Burns & Adam P. Hill & Derek Laver & Carol V. Robinson , 2020. "A constricted opening in Kir channels does not impede potassium conduction," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    4. Campos de Oliveira, R.A. & Barbosa, C.T.F. & Consoni, L.H.A. & Rodrigues, A.R.A. & Varanda, W.A. & Nogueira, R.A., 2006. "Long-term correlation in single calcium-activated potassium channel kinetics," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 364(C), pages 13-22.
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    Cited by:

    1. Borys, Przemysław & Trybek, Paulina & Dworakowska, Beata & Sekrecka-Belniak, Anna & Nurowska, Ewa & Bednarczyk, Piotr & Wawrzkiewicz-Jałowiecka, Agata, 2024. "Selectivity filter conductance, rectification and fluctuations of subdomains—How can this all relate to the value of Hurst exponent in the dwell-times of ion channels states?," Chaos, Solitons & Fractals, Elsevier, vol. 180(C).

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