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Confidence interval construction for the Youden index based on partially validated series

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  • Poon, Wai-Yin
  • Qiu, Shi-Fang
  • Tang, Man-Lai

Abstract

Confidence interval construction for the Youden index of a diagnostic test based on partially validated series with dichotomous response is considered in this article. Using the Wald and Agresti-Coull, the Wilson score, logit-transformation and the method of variance estimates recovery, eight methods for constructing confidence intervals for a single Youden index and nine methods for the difference between two independent Youden indices are developed. Comparisons among the various methods with respect to their empirical coverage probabilities and confidence interval widths are conducted through simulation studies over a variety of parameter settings. Based on the simulation results, recommendations for practical use under different conditions are provided. A real aplastic anemia data set is used to illustrate the proposed methods.

Suggested Citation

  • Poon, Wai-Yin & Qiu, Shi-Fang & Tang, Man-Lai, 2015. "Confidence interval construction for the Youden index based on partially validated series," Computational Statistics & Data Analysis, Elsevier, vol. 84(C), pages 116-134.
    • Handle: RePEc:eee:csdana:v:84:y:2015:i:c:p:116-134
    DOI: 10.1016/j.csda.2014.11.013
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    References listed on IDEAS

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    1. Lai, Chin-Ying & Tian, Lili & Schisterman, Enrique F., 2012. "Exact confidence interval estimation for the Youden index and its corresponding optimal cut-point," Computational Statistics & Data Analysis, Elsevier, vol. 56(5), pages 1103-1114.
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