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Nonlinear random effects mixture models: Maximum likelihood estimation via the EM algorithm

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  • Wang, Xiaoning
  • Schumitzky, Alan
  • D'Argenio, David Z.

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  • Wang, Xiaoning & Schumitzky, Alan & D'Argenio, David Z., 2007. "Nonlinear random effects mixture models: Maximum likelihood estimation via the EM algorithm," Computational Statistics & Data Analysis, Elsevier, vol. 51(12), pages 6614-6623, August.
    • Handle: RePEc:eee:csdana:v:51:y:2007:i:12:p:6614-6623
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    References listed on IDEAS

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    1. Geweke, John, 1989. "Bayesian Inference in Econometric Models Using Monte Carlo Integration," Econometrica, Econometric Society, vol. 57(6), pages 1317-1339, November.
    2. A. Philippou & G. Roussas, 1975. "Asymptotic normality of the maximum likelihood estimate in the independent not identically distributed case," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 27(1), pages 45-55, December.
    3. Kuhn, E. & Lavielle, M., 2005. "Maximum likelihood estimation in nonlinear mixed effects models," Computational Statistics & Data Analysis, Elsevier, vol. 49(4), pages 1020-1038, June.
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    Cited by:

    1. Wang, Xiaoning & Schumitzky, Alan & D'Argenio, David Z., 2009. "Population pharmacokinetic/pharmacodynamic mixture models via maximum a posteriori estimation," Computational Statistics & Data Analysis, Elsevier, vol. 53(12), pages 3907-3915, October.
    2. Yangxin Huang & Xiaosun Lu & Jiaqing Chen & Juan Liang & Miriam Zangmeister, 2018. "Joint model-based clustering of nonlinear longitudinal trajectories and associated time-to-event data analysis, linked by latent class membership: with application to AIDS clinical studies," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 24(4), pages 699-718, October.
    3. Antic, J. & Laffont, C.M. & Chafaï, D. & Concordet, D., 2009. "Comparison of nonparametric methods in nonlinear mixed effects models," Computational Statistics & Data Analysis, Elsevier, vol. 53(3), pages 642-656, January.
    4. Fu, Liyong & Wang, Mingliang & Lei, Yuancai & Tang, Shouzheng, 2014. "Parameter estimation of two-level nonlinear mixed effects models using first order conditional linearization and the EM algorithm," Computational Statistics & Data Analysis, Elsevier, vol. 69(C), pages 173-183.

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