IDEAS home Printed from https://ideas.repec.org/a/caa/jnlvet/v57y2012i9id6336-vetmed.html
   My bibliography  Save this article

Single-domain antibody fragments derived from heavy-chain antibodies: a review

Author

Listed:
  • L. Eyer

    (Veterinary Research Institute, Brno, Czech Republic)

  • K. Hruska

    (Veterinary Research Institute, Brno, Czech Republic)

Abstract

Single-domain antibody (sdAb) fragments derived from heavy-chain antibodies of camelids and cartilaginous fish represent a new generation of therapeutic agents and immunoreagents. Due to their unique characteristics, such as low molecular weight, high physical-chemical stability, good water solubility, and the ability to bind antigens inaccessible to conventional antibodies, they could potentially act as a substitute for conventional therapeutic drugs in the treatment of serious human diseases, and, moreover, could be broadly used in analyses and diagnostics. In this review article, an analysis of 826 publications oriented to heavy-chain antibodies and their sdAb fragments indexed in the Web of Science® database since 1993 has been carried out. Attention has predominantly been paid to papers published from 2010 to June 2012. Key publications are presented in tables and are characterised by descriptive words, abstracts and references. The presented publications have been sorted according to seven basic criteria: review articles and monographs, heavy-chain antibodies of camelids and sharks, production of sdAb fragments using recombinant technology, characteristic properties of sdAb fragments, application of sdAb fragments in therapy, application of sdAb fragments in diagnostic and immunoanalytical methods and other prospective uses of sdAb fragments. This review article should highlight the typical properties of heavy-chain antibodies and sdAb fragments which differentiate them from conventional antibodies and other available recombinant fragments, and also emphasize their extremely broad application potential, mainly in human disease therapy. At the same time it allows an easy and rapid orientation in numerous publications written on this subject, and facilitates the search for the required data.

Suggested Citation

  • L. Eyer & K. Hruska, 2012. "Single-domain antibody fragments derived from heavy-chain antibodies: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 57(9), pages 439-513.
    • Handle: RePEc:caa:jnlvet:v:57:y:2012:i:9:id:6336-vetmed
    DOI: 10.17221/6336-VETMED
    as

    Download full text from publisher

    File URL: http://vetmed.agriculturejournals.cz/doi/10.17221/6336-VETMED.html
    Download Restriction: free of charge
    File URL: http://vetmed.agriculturejournals.cz/doi/10.17221/6336-VETMED.pdf
    Download Restriction: free of charge
    File URL: https://libkey.io/10.17221/6336-VETMED?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. K. Hruska & M. Kaevska, 2012. "Mycobacteria in water, soil, plants and air: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 57(12), pages 623-679.
    2. L. Eyer & K. Hruska, 2013. "Antiviral agents targeting the influenza virus: a review and publication analysis," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 58(3), pages 113-185.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:caa:jnlvet:v:57:y:2012:i:9:id:6336-vetmed. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Ivo Andrle (email available below). General contact details of provider: https://www.cazv.cz/en/home/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.