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Genetic basis of resistance to quaternary ammonium compounds - the qac genes and their role: a review

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  • Z. Jaglic

    (Veterinary Research Institute, Brno, Czech Republic)

  • D. Cervinkova

    (Veterinary Research Institute, Brno, Czech Republic)

Abstract

Although the qac genes are named after one of their main substrates (i.e., quaternary ammonium compounds), these genes also code for resistance to a broad spectrum of other cationic compounds such as intercalating dyes, diamidines and biguanides. The various Qac proteins are involved in relatively low specific efflux-based multidrug pumps and belong to a family of small multidrug resistance proteins. Even though the practical significance of qac-mediated resistance lies mainly in resistance to antiseptics, contradictory findings on this issue are still reported. Therefore, the aim of this review is to summarise the current knowledge on qac-mediated resistance with special emphasis on resistance to antiseptics and its relevance for practice.

Suggested Citation

  • Z. Jaglic & D. Cervinkova, 2012. "Genetic basis of resistance to quaternary ammonium compounds - the qac genes and their role: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 57(6), pages 275-281.
    • Handle: RePEc:caa:jnlvet:v:57:y:2012:i:6:id:6013-vetmed
    DOI: 10.17221/6013-VETMED
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    References listed on IDEAS

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    1. Zoran Jaglic & Dana Červinková & Hana Vlková & Elleni Michu & Gabriela Kunová & Vladimír Babák, 2012. "Bacterial biofilms resist oxidising agents due to the presence of organic matter," Czech Journal of Food Sciences, Czech Academy of Agricultural Sciences, vol. 30(2), pages 178-187.
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    Cited by:

    1. Y. Ergun & Z. Cantekin & K. Gurturk & H. Solmaz & I.H. Ekin & D. Ozturk, 2017. "Distribution of antiseptic resistance genes in Staphylococcus spp. from bovine mastitis," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 62(4), pages 200-203.

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