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Diagnosis of tularemia using biochemical, immunochemical and molecular methods: a review

Author

Listed:
  • M. Pohanka

    (Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic)

  • R. Chlibek

    (Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic)

  • K. Kuca

    (Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic)

  • H. Bandouchova

    (Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic)

  • J. Pikula

    (Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic)

Abstract

Tularemia, an infection caused by the intracellular gram-negative bacterium Francisella tularensis, is accompanied by high mortality and occurs throughout the Northern Hemisphere. The causative agent is also considered one of the most important biological warfare agents. As well as its taxonomy and epidemiology, the basic immunochemical, biochemical, and molecular approaches for disease diagnosis are outlined in this review. Aspects of immune responses during tularemia and damage to specific organs are discussed with regards to the predictive value of standard biomarkers. Bacterial burden is also considered as a limitation for polymerase-chain-reaction-based diagnosis.

Suggested Citation

  • M. Pohanka & R. Chlibek & K. Kuca & H. Bandouchova & J. Pikula, 2011. "Diagnosis of tularemia using biochemical, immunochemical and molecular methods: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 56(9), pages 453-461.
    • Handle: RePEc:caa:jnlvet:v:56:y:2011:i:9:id:3207-vetmed
    DOI: 10.17221/3207-VETMED
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    References listed on IDEAS

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    1. F. Treml & J. Pikula & H. Bandouchova & J. Horakova, 2007. "European brown hare as a potential source of zoonotic agents," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 52(10), pages 451-456.
    2. M. Pohanka & M. Hubalek & V. Neubauerova & A. Macela & M. Faldyna & H. Bandouchova & J. Pikula, 2008. "Current and emerging assays for Francisella tularensis detection: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 53(11), pages 585-594.
    3. J. Pikula & M. Beklova & Z. Holesovska & F. Treml, 2004. "Prediction of possible distribution of tularemia in the Czech Republic," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 49(2), pages 61-64.
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