IDEAS home Printed from https://ideas.repec.org/a/caa/jnlvet/v54y2009i2id1913-vetmed.html
   My bibliography  Save this article

Susceptibility of selected murine and microtine species to infection by a wild strain of Francisella tularensis subsp. holoarctica

Author

Listed:
  • H. Bandouchova

    (University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic)

  • J. Sedlackova

    (University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic)

  • M. Hubalek

    (University of Defence, Hradec Kralove, Czech Republic)

  • M. Pohanka

    (University of Defence, Hradec Kralove, Czech Republic)

  • L. Peckova

    (University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic)

  • F. Treml

    (University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic)

  • F. Vitula

    (University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic)

  • J. Pikula

    (University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic)

Abstract

The purpose of this study was to compare susceptibility of BALB/c mice, common voles (Microtus arvalis) and yellow-necked mice (Apodemus flavicollis) to infection by a virulent Francisella tularensis subsp. holarctica strain. Median survival in these three species following experimental infection with 320 colony forming units of F. tularensis (both intraperitoneally and subcutaneously) amounted to 4.5, 7 and 4 days, respectively. Survival curves of BALB/c and yellow-necked mice were very similar and were significantly different from that of common voles. LD50 was 0.5 and 37.9 colony forming units in BALB/c mice and common voles, respectively. The bacterial burden in the spleen, liver, lung, kidney and blood of common voles started to develop later post exposure and amounted to lower levels (except in kidneys) than in BALB/c mice. The results demonstrate that yellow-necked mice are even more susceptible to infection by F. tularensis than BALB/c mice and that the common vole is a small mammalian host with a susceptibility which is two-orders-of-magnitude lower.

Suggested Citation

  • H. Bandouchova & J. Sedlackova & M. Hubalek & M. Pohanka & L. Peckova & F. Treml & F. Vitula & J. Pikula, 2009. "Susceptibility of selected murine and microtine species to infection by a wild strain of Francisella tularensis subsp. holoarctica," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 54(2), pages 64-74.
  • Handle: RePEc:caa:jnlvet:v:54:y:2009:i:2:id:1913-vetmed
    DOI: 10.17221/1913-VETMED
    as

    Download full text from publisher

    File URL: http://vetmed.agriculturejournals.cz/doi/10.17221/1913-VETMED.html
    Download Restriction: free of charge

    File URL: http://vetmed.agriculturejournals.cz/doi/10.17221/1913-VETMED.pdf
    Download Restriction: free of charge

    File URL: https://libkey.io/10.17221/1913-VETMED?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. M. Pohanka & M. Hubalek & V. Neubauerova & A. Macela & M. Faldyna & H. Bandouchova & J. Pikula, 2008. "Current and emerging assays for Francisella tularensis detection: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 53(11), pages 585-594.
    2. F. Treml & J. Pikula & H. Bandouchova & J. Horakova, 2007. "European brown hare as a potential source of zoonotic agents," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 52(10), pages 451-456.
    3. J. Piskula & M. Beklova & Z. Holesovska & F. Treml, 2004. "Spatio-temporal aspects of tularemia in Southern Moravia, Czech Republic," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 49(1), pages 15-18.
    4. J. Pikula & M. Beklova & Z. Holesovska & F. Treml, 2004. "Prediction of possible distribution of tularemia in the Czech Republic," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 49(2), pages 61-64.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. M. Pohanka & R. Chlibek & K. Kuca & H. Bandouchova & J. Pikula, 2011. "Diagnosis of tularemia using biochemical, immunochemical and molecular methods: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 56(9), pages 453-461.
    2. M. Pohanka & M. Hubalek & V. Neubauerova & A. Macela & M. Faldyna & H. Bandouchova & J. Pikula, 2008. "Current and emerging assays for Francisella tularensis detection: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 53(11), pages 585-594.
    3. K. Chroust & M. Vodnansky & J. Pikula, 2012. "Parasite load of European brown hares in Austria and the Czech Republic," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 57(10), pages 551-558.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:caa:jnlvet:v:54:y:2009:i:2:id:1913-vetmed. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Ivo Andrle (email available below). General contact details of provider: https://www.cazv.cz/en/home/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.