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Effects of Nigella sativa and silver sulfadiazine on burn wound healing in rats

Author

Listed:
  • I. Yaman

    (Faculty of Veterinary Medicine, University of Firat, Elazig, Turkey)

  • A.S. Durmus

    (Faculty of Veterinary Medicine, University of Firat, Elazig, Turkey)

  • S. Ceribasi

    (Faculty of Veterinary Medicine, University of Firat, Elazig, Turkey)

  • M. Yaman

    (Faculty of Veterinary Medicine, University of Firat, Elazig, Turkey)

Abstract

This experiment was conducted in order to compare the effects of Nigella sativa (NS) and silver sulfadiazine (SSD) cream on healing of burn wounds in rats. Fifty four adult, male Wistar-albino rats were divided into three groups of equal numbers. A burn was generated on the backs of all the rats. The burned areas in the first, second and third groups were covered with daily cold cream (control), SSD cream and NS cream (50% NS oil + 50% cold cream), respectively. Four, nine, and 14 days later, the rats were sacrificed and the burned skin tissue samples were collected for histopathological examinations. Histopatological evaluations on the 4th, 9th and 14th days showed burn healing to be better in the NS and SSD groups with respect to the control group. Wound healing was significantly different among the groups at 4th, 9th and 14th days (P < 0.001). In conclusion, application of NS and SSD cream are effective in healing burn related skin wounds in the rat model.

Suggested Citation

  • I. Yaman & A.S. Durmus & S. Ceribasi & M. Yaman, 2010. "Effects of Nigella sativa and silver sulfadiazine on burn wound healing in rats," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 55(12), pages 619-624.
    • Handle: RePEc:caa:jnlvet:v:55:y:2010:i:12:id:2948-vetmed
    DOI: 10.17221/2948-VETMED
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    Citations

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    Cited by:

    1. A.S. Durmus & M. Yaman & H.N. Can, 2012. "Effects of extractum cepae, heparin, allantoin gel and silver sulfadiazine on burn wound healing: an experimental study in a rat model," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 57(6), pages 287-292.
    2. F. Sabol & L. Dancakova & P. Gal & T. Vasilenko & M. Novotny & K. Smetana & L. Lenhardt, 2012. "Immunohistological changes in skin wounds during the early periods of healing in a rat model," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 57(2), pages 77-82.

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