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Nitrofuran antibiotics: a review on the application, prohibition and residual analysis

Author

Listed:
  • M. Vass
  • K. Hruska

    (Veterinary Research Institute, Brno, Czech Republic)

  • M. Franek

    (Veterinary Research Institute, Brno, Czech Republic)

Abstract

Nitrofuran antibiotics, employed for the treatment of bacterial diseases in livestock production, were banned from use in the European Union (EU) in 1995 due to concerns about the carcinogenicity of their residues in edible tissue. This review provides an overview of nitrofuran toxicity, metabolism, and also specific aspects of legislation surrounding their prohibition. Special attention is devoted to semicarbazide - a nitrofuran metabolite and food contaminant. Analytical procedures for nitrofuran analysis in various matrices and validation requirements for screening and confirmation methods with respect to EU regulations are also reviewed.

Suggested Citation

  • M. Vass & K. Hruska & M. Franek, 2008. "Nitrofuran antibiotics: a review on the application, prohibition and residual analysis," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 53(9), pages 469-500.
  • Handle: RePEc:caa:jnlvet:v:53:y:2008:i:9:id:1979-vetmed
    DOI: 10.17221/1979-VETMED
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    References listed on IDEAS

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    1. M. Franek & I. Diblikova & M. Vass & L. Kotkova & K. Stastny & K. Frgalova & K. Hruska, 2006. "Validation of a monoclonal antibody-based ELISA for the quantification of the furazolidone metabolite (AOZ) in eggs using various sample preparation," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 51(5), pages 248-257.
    2. M. Vass & L. Kotkova & I. Diblikova & Z. Nevorankova & K.M. Cooper & D.G. Kennedy & M. Franek, 2005. "Production and characterisation of monoclonal antibodies for the detection of AOZ, a tissue bound metabolite of furazolidone," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 50(7), pages 300-310.
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    Cited by:

    1. K. Hruska & M. Franek, 2009. "Rapid Alert System for Food and Feed: the semicarbazide notifications," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 54(11), pages 561-564.
    2. L. Eyer & K. Hruska, 2013. "Antiviral agents targeting the influenza virus: a review and publication analysis," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 58(3), pages 113-185.

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    1. M. Franek & I. Diblikova & M. Vass & L. Kotkova & K. Stastny & K. Frgalova & K. Hruska, 2006. "Validation of a monoclonal antibody-based ELISA for the quantification of the furazolidone metabolite (AOZ) in eggs using various sample preparation," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 51(5), pages 248-257.

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