IDEAS home Printed from https://ideas.repec.org/a/caa/jnlvet/v52y2007i2id2053-vetmed.html
   My bibliography  Save this article

Phytoestrogens reduce the effect of polychlorinated biphenyls on the contractility of bovine myometrium in vitro

Author

Listed:
  • M. Wrobel

    (Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland)

  • J. Kotwica

    (Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland)

Abstract

Proper regulation of uterine contractility, both spontaneous and oxytocin (OT)-amplified, is essential for successful fertilization and maintenance of gestation. Previously, we showed that polychlorinated biphenyls (PCBs), regarded as environmental pollutants, contributed to the increase in contractions of cyclic bovine uterus. In this paper, we hypothesized that phytoestrogens, plant-derived components, counteract the disruptive effects of PCBs. Therefore, we examined the in vitro effect (24-72 h) of coumestrol, daidzein, and genistein (10-6, 10-5M each) on spontaneous and OT-stimulated (10-7M) myometrial strips contractions. Moreover, the effect (48 h) of coumestrol (10-6M) or daidzein (10-5M), jointly with PCBs (77, 100 ng/ml; 126, 153, 10 ng/ml), on myometrial contractions was registered. The myometrium was the most relaxed (P < 0.05) when treated with coumestrol, while the force of myometrial spontaneous contractions increased the most (P < 0.05) when treated with daidzein. Daidzein (10-5M) also effectively increased the OT-stimulated force of contractions (P < 0.01). All phytoestrogens used affected the frequency and amplitude of myometrial contractions, though less markedly. Furthermore, coumestrol or daidzein reduced (P < 0.05) the spontaneous and OT-stimulated force of myometrial contractions, evoked by PCBs. Data suggest the effect of PCBs on myometrial contractility can be markedly reduced by some phytoestrogens.

Suggested Citation

  • M. Wrobel & J. Kotwica, 2007. "Phytoestrogens reduce the effect of polychlorinated biphenyls on the contractility of bovine myometrium in vitro," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 52(2), pages 55-62.
    • Handle: RePEc:caa:jnlvet:v:52:y:2007:i:2:id:2053-vetmed
    DOI: 10.17221/2053-VETMED
    as

    Download full text from publisher

    File URL: http://vetmed.agriculturejournals.cz/doi/10.17221/2053-VETMED.html
    Download Restriction: free of charge
    File URL: http://vetmed.agriculturejournals.cz/doi/10.17221/2053-VETMED.pdf
    Download Restriction: free of charge
    File URL: https://libkey.io/10.17221/2053-VETMED?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. J.J. Mlynarczuk & J. Kotwica, 2006. "Effect of polychlorinated biphenyls on the secretion of oxytocin from luteal and granulosa cells in cow: possible involvement of glucocorticoid receptors," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 51(7), pages 391-398.
    2. M. Franek & K. Hruska, 2005. "Antibody based methods for environmental and food analysis: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 50(1), pages 1-10.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. R. Rekawiecki & J. Kotwica, 2007. "Molecular regulation of progesterone synthesis in the bovine corpus luteum," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 52(9), pages 405-412.
    2. K. Hruska & M. Franek, 2012. "Sulfonamides in the environment: a review and a case report," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 57(1), pages 1-35.
    3. K. Hruska, 2006. "Veterinary Research Institute, Brno, Czech Republic: Analysis of papers published from 1990 to 2005," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 51(5), pages 161-167.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:caa:jnlvet:v:52:y:2007:i:2:id:2053-vetmed. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Ivo Andrle (email available below). General contact details of provider: https://www.cazv.cz/en/home/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.