IDEAS home Printed from https://ideas.repec.org/a/caa/jnlvet/v51y2006i7id5559-vetmed.html
   My bibliography  Save this article

Effect of polychlorinated biphenyls on the secretion of oxytocin from luteal and granulosa cells in cow: possible involvement of glucocorticoid receptors

Author

Listed:
  • J.J. Mlynarczuk

    (Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland)

  • J. Kotwica

    (Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland)

Abstract

Polychlorinated biphenyls (PCBs) stimulate oxytocin secretion from bovine granulosa and luteal cells. Since oxytocin on the one hand is released from ovarian cells by cortisol and on the other hand PCBs can be bound by glucocorticoid receptors (GCr), we have tested the hypothesis that PCBs acting via GCr can stimulate oxytocin secretion. In preliminary studies the effect of RU486 (GCr blocker) on cells viability was tested. Thereafter, a selected dose of RU486 (105M), which did not affect cell viability, was used in further experiments. It appears that this dose of RU486 completely blocked GCr against cortisol-stimulated oxytocin secretion, in both types of cells. Furthermore, granulosa cells (105) from follicles of two sizes (>1 cm < in diameter) and luteal cells (105) from day 5-10 of estrous cycle were incubated for 72 h with congeners of PCB (126, 77 or 153) at doses of 1, 10 or 100 ng/ml each, separately or jointly with RU486. The effect of PCB 77 and 153 on oxytocin secretion was blocked by RU486, but it did not change the effect evoked by PCB126 in both granulosa and luteal cells. We assume that some PCB congeners can affect oxytocin secretion from granulosa and luteal cells acting via GCr.

Suggested Citation

  • J.J. Mlynarczuk & J. Kotwica, 2006. "Effect of polychlorinated biphenyls on the secretion of oxytocin from luteal and granulosa cells in cow: possible involvement of glucocorticoid receptors," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 51(7), pages 391-398.
  • Handle: RePEc:caa:jnlvet:v:51:y:2006:i:7:id:5559-vetmed
    DOI: 10.17221/5559-VETMED
    as

    Download full text from publisher

    File URL: http://vetmed.agriculturejournals.cz/doi/10.17221/5559-VETMED.html
    Download Restriction: free of charge

    File URL: http://vetmed.agriculturejournals.cz/doi/10.17221/5559-VETMED.pdf
    Download Restriction: free of charge

    File URL: https://libkey.io/10.17221/5559-VETMED?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. J. Mlynarczuk & R. Amarowicz & J. Kotwica, 2003. "Effect of polychlorinated biphenyls (Aroclor-1248) on the secretory function of bovine luteal cells affected by LH, noradrenaline and high density lipoproteins," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 48(10), pages 267-274.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. M. Wrobel & J. Kotwica, 2007. "Phytoestrogens reduce the effect of polychlorinated biphenyls on the contractility of bovine myometrium in vitro," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 52(2), pages 55-62.
    2. R. Rekawiecki & J. Kotwica, 2007. "Molecular regulation of progesterone synthesis in the bovine corpus luteum," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 52(9), pages 405-412.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:caa:jnlvet:v:51:y:2006:i:7:id:5559-vetmed. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Ivo Andrle (email available below). General contact details of provider: https://www.cazv.cz/en/home/ .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.