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Two single nucleotide polymorphisms in the caprine GnIH gene are associated with litter size

Author

Listed:
  • Xiaopeng An

    (College of Animal Science and Technology, Northwest A&F University, Yangling, P.R. China)

  • Lijuan Bao

    (College of Animal Science and Technology, Northwest A&F University, Yangling, P.R. China)

  • Jinxing Hou

    (College of Animal Science and Technology, Northwest A&F University, Yangling, P.R. China)

  • Yueyu Bai

    (Animal Health Supervision Institute of Henan Province, Zhengzhou, P.R. China)

  • Xinyan Zhao

    (Northwest A&F University of Hospital, Northwest A&F University, Yangling, P.R. China)

  • Yuxuan Song

    (College of Animal Science and Technology, Northwest A&F University, Yangling, P.R. China)

  • Binyun Cao

    (College of Animal Science and Technology, Northwest A&F University, Yangling, P.R. China)

Abstract

Gonadotropin-inhibitory hormone (GnIH) can decrease luteinizing hormone and/or follicle-stimulating hormone levels in rat, mouse, sheep, and cattle by the direct suppression of gonadotropin-releasing hormone (GnRH). The present study investigated polymorphisms in the GnIH genes of two dairy goat breeds and their association with litter size. Single nucleotide polymorphisms (SNPs) g.1837C>G and g.3195G>A (GenBank Accession Nos. KR778885 and KR819142) were detected in the GnIH genes of Xinong Saanen and Guanzhong dairy goat breeds using DNA sequencing and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Furthermore, the g.1837C>G and g.3195G>A loci were closely linked in both breeds (r2 > 0.33). Association analysis showed that these SNPs had significant effects on the litter size of goats (P < 0.05). In both breeds, individuals with the CC/GG (g.1837C>G/g.3195G>A) genotype showed larger litter sizes in the second and average parities than individuals with the GG/AA genotype (P < 0.05). Known biochemical and physiological functions, along with our results, indicate that the CC/GG genotype may be used in marker-assisted selection to choose individuals with a larger litter size from both breeds.

Suggested Citation

  • Xiaopeng An & Lijuan Bao & Jinxing Hou & Yueyu Bai & Xinyan Zhao & Yuxuan Song & Binyun Cao, 2017. "Two single nucleotide polymorphisms in the caprine GnIH gene are associated with litter size," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 62(7), pages 269-275.
    • Handle: RePEc:caa:jnlcjs:v:62:y:2017:i:7:id:58-2016-cjas
    DOI: 10.17221/58/2016-CJAS
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    References listed on IDEAS

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    1. M. Pasandideh & M.R. Mohammadabadi & A.K. Esmailizadeh & A. Tarang, 2015. "Association of bovine PPARGC1A and OPN genes with milk production and composition in Holstein cattle," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 60(3), pages 97-104.
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