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Association of bovine PPARGC1A and OPN genes with milk production and composition in Holstein cattle

Author

Listed:
  • M. Pasandideh

    (Young Researchers and Elite Club, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran)

  • M.R. Mohammadabadi

    (Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran)

  • A.K. Esmailizadeh

    (Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran)

  • A. Tarang

    (Department of Genomics, Branch of North Region of Iran (Rasht), Agricultural Biotechnology Research Institute of Iran, Rasht, Iran)

Abstract

Several studies have reported quantitative trait loci on chromosome 6 affecting milk production and composition traits in dairy cattle. Osteopontin (OPN) and peroxisome proliferator activated receptor-γ coactivator-1α (PPARGC1A) genes have been located on this chromosome and identified as positional candidates for milk traits. We investigated the associations of single nucleotide polymorphism (SNP) T>C at position 1892 and SNP A>C at position 3359 in PPARGC1A gene as well as SNP C>T at position 8514 in OPN gene with milk production and composition. Hence, 398 Iranian Holstein cows were genotyped through polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The Least Squares methods were used to examine the effects of genotypes on milk traits. The frequencies of the C allele at position 1892, A allele at position 3359, and T allele at position 8514 were 0.56, 0.64, and 0.53, respectively. In this study, c.1892T>C genotypes indicated significant associations with milk fat content adjusted for two milkings per day (FATP2X; %), estimated breeding value for milk (EBVM; kg), milk protein yield adjusted for mature body weight (PROME; kg), milk protein yield adjusted for 305 days (PRO305; kg) (P < 0.05), and estimated breeding value for milk fat content (EBVFP; %) (P < 0.01). There were significant associations between c.3359A>C genotypes and FATP2X, EBVFP (P < 0.01). Moreover, significant associations were shown between c.8514C>T genotypes in OPN gene and FATP2X (P < 0.05), and PROPER305 (P < 0.01). Thus, these SNPs would provide an excellent opportunity for marker assisted selection programs in dairy cattle.

Suggested Citation

  • M. Pasandideh & M.R. Mohammadabadi & A.K. Esmailizadeh & A. Tarang, 2015. "Association of bovine PPARGC1A and OPN genes with milk production and composition in Holstein cattle," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 60(3), pages 97-104.
  • Handle: RePEc:caa:jnlcjs:v:60:y:2015:i:3:id:8074-cjas
    DOI: 10.17221/8074-CJAS
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    References listed on IDEAS

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    1. I. Kowalewska-Łuczak & H. Kulig & M. Kmieć, 2010. "Associations between the bovine PPARGC1A gene and milk production traits," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 55(5), pages 195-199.
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    Cited by:

    1. Jindřich Čítek & Lenka Hanusová & Michaela Brzáková & Libor Večerek & Lothar Panicke & Lucie Lískovcová, 2018. "Associations between gene polymorphisms, breeding values, and glucose tolerance test parameters in German Holstein sires," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 63(5), pages 167-173.
    2. Xiaopeng An & Lijuan Bao & Jinxing Hou & Yueyu Bai & Xinyan Zhao & Yuxuan Song & Binyun Cao, 2017. "Two single nucleotide polymorphisms in the caprine GnIH gene are associated with litter size," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 62(7), pages 269-275.

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    Keywords

    cattle; OPN; PCR-RFLP; PPARGC1A; SNPs;
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