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Antimutagenic effect of curcumin and its effect on the immune response in mice

Author

Listed:
  • Petr Šmerák

    (Department of General Biology and Genetics and 4Department of General Hygiene, Center of Biomedical Science, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic)

  • Zdeňka Polívková

    (Department of General Biology and Genetics and 4Department of General Hygiene, Center of Biomedical Science, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic)

  • Helena Šestáková

    (National Institute of Public Health, Prague, Czech Republic)

  • Rudolf Štětina

    (Faculty of Military Health Sciences, Department of Toxicology, Hradec Kralové, Czech Republic)

  • Ivo Bárta

    (Department of General Biology and Genetics and 4Department of General Hygiene, Center of Biomedical Science, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic)

  • Martina Langová

    (Department of General Biology and Genetics and 4Department of General Hygiene, Center of Biomedical Science, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic)

  • Bohumil Turek

    (National Institute of Public Health, Prague, Czech Republic)

  • Jiřina Bártová

Abstract

A wide array of antioxidative and anti-inflammatory substances derived from edible plants have been reported to possess chemopreventive and chemoprotective activities. Among the most extensively investigated and well-defined dietary chemopreventives is curcumin. Using the Ames test and in vivo micronucleus test, chemiluminescence test, blastic transformation test, and comet assay, we examined the antimutagenic effects of the chemically identified chemoprotective substance curcumin (diferuloylmethane) in the pure form on mutagenicity induced by three reference mutagens: aflatoxin B1 (AFB1), 2-amino-3-metylimidazo[4,5-f]quinoline (IQ), and N-nitroso-N-metylurea (MNU), and the effect of curcumin on the immunosuppression caused by these mutagens. Curcumin in the pure form showed a clear antimutagenic and immunomodulatory activities on mutagenicity and immunosuppression induced by reference mutagens.

Suggested Citation

  • Petr Šmerák & Zdeňka Polívková & Helena Šestáková & Rudolf Štětina & Ivo Bárta & Martina Langová & Bohumil Turek & Jiřina Bártová, 2006. "Antimutagenic effect of curcumin and its effect on the immune response in mice," Czech Journal of Food Sciences, Czech Academy of Agricultural Sciences, vol. 24(2), pages 72-83.
    • Handle: RePEc:caa:jnlcjf:v:24:y:2006:i:2:id:3302-cjfs
    DOI: 10.17221/3302-CJFS
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    Cited by:

    1. Petr Šmerák & Helena Šestáková & Zdeňka Polívková & Rudolf Štětina & Martina Langová & Ivo Bárta & Bohumil Turek & Jiřina Bártová, 2006. "Antimutagenic effect of epigallocatechin gallate and its effect on the immune response in mice," Czech Journal of Food Sciences, Czech Academy of Agricultural Sciences, vol. 24(4), pages 180-192.

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