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A Spatio-Temporal Model and Inference Tools for Longitudinal Count Data on Multicolor Cell Growth

Author

Listed:
  • Qiao PuXue

    (The University of Melbourne, Melbourne, Australia)

  • Mølck Christina

    (The University of Melbourne, Melbourne, Australia)

  • Ferrari Davide

    (Free University of Bozen-Bolzano, Bolzano, Italy)

  • Hollande Frédéric

    (The University of Melbourne, Melbourne, Australia)

Abstract

Multicolor cell spatio-temporal image data have become important to investigate organ development and regeneration, malignant growth or immune responses by tracking different cell types both in vivo and in vitro. Statistical modeling of image data from common longitudinal cell experiments poses significant challenges due to the presence of complex spatio-temporal interactions between different cell types and difficulties related to measurement of single cell trajectories. Current analysis methods focus mainly on univariate cases, often not considering the spatio-temporal effects affecting cell growth between different cell populations. In this paper, we propose a conditional spatial autoregressive model to describe multivariate count cell data on the lattice, and develop inference tools. The proposed methodology is computationally tractable and enables researchers to estimate a complete statistical model of multicolor cell growth. Our methodology is applied on real experimental data where we investigate how interactions between cancer cells and fibroblasts affect their growth, which are normally present in the tumor microenvironment. We also compare the performance of our methodology to the multivariate conditional autoregressive (MCAR) model in both simulations and real data applications.

Suggested Citation

  • Qiao PuXue & Mølck Christina & Ferrari Davide & Hollande Frédéric, 2018. "A Spatio-Temporal Model and Inference Tools for Longitudinal Count Data on Multicolor Cell Growth," The International Journal of Biostatistics, De Gruyter, vol. 14(2), pages 1-18, November.
    • Handle: RePEc:bpj:ijbist:v:14:y:2018:i:2:p:18:n:5
    DOI: 10.1515/ijb-2018-0008
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    References listed on IDEAS

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    1. Richard A. Davis, 2003. "Observation-driven models for Poisson counts," Biometrika, Biometrika Trust, vol. 90(4), pages 777-790, December.
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