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Subgroup selection in adaptive signature designs of confirmatory clinical trials

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  • Zhiwei Zhang
  • Meijuan Li
  • Min Lin
  • Guoxing Soon
  • Tom Greene
  • Changyu Shen

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Suggested Citation

  • Zhiwei Zhang & Meijuan Li & Min Lin & Guoxing Soon & Tom Greene & Changyu Shen, 2017. "Subgroup selection in adaptive signature designs of confirmatory clinical trials," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 66(2), pages 345-361, February.
    • Handle: RePEc:bla:jorssc:v:66:y:2017:i:2:p:345-361
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    File URL: http://hdl.handle.net/10.1111/rssc.12175
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    References listed on IDEAS

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    1. Baqun Zhang & Anastasios A. Tsiatis & Eric B. Laber & Marie Davidian, 2012. "A Robust Method for Estimating Optimal Treatment Regimes," Biometrics, The International Biometric Society, vol. 68(4), pages 1010-1018, December.
    2. Zhiwei Zhang & Chenguang Wang & Lei Nie & Guoxing Soon, 2013. "Assessing the heterogeneity of treatment effects via potential outcomes of individual patients," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 62(5), pages 687-704, November.
    3. Yingqi Zhao & Donglin Zeng & A. John Rush & Michael R. Kosorok, 2012. "Estimating Individualized Treatment Rules Using Outcome Weighted Learning," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 107(499), pages 1106-1118, September.
    4. M. Rosenblum & M. J. van der Laan, 2011. "Optimizing randomized trial designs to distinguish which subpopulations benefit from treatment," Biometrika, Biometrika Trust, vol. 98(4), pages 845-860.
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    Cited by:

    1. Helen Yvette Barnett & Sofía S. Villar & Helena Geys & Thomas Jaki, 2023. "A novel statistical test for treatment differences in clinical trials using a response‐adaptive forward‐looking Gittins Index Rule," Biometrics, The International Biometric Society, vol. 79(1), pages 86-97, March.
    2. Nigel Stallard, 2023. "Adaptive enrichment designs with a continuous biomarker," Biometrics, The International Biometric Society, vol. 79(1), pages 9-19, March.

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