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Generalized accelerated recurrence time model for multivariate recurrent event data with missing event type

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  • Huijuan Ma
  • Limin Peng
  • Zhumin Zhang
  • HuiChuan J. Lai

Abstract

Recurrent events data are frequently encountered in biomedical follow‐up studies. The generalized accelerated recurrence time (GART) model (Sun et al., 2016), which formulates covariate effects on the time scale of the mean function of recurrent events (i.e., time to expected frequency), has arisen as a useful secondary analysis tool to provide meaningful physical interpretations. In this article, we investigate the GART model in a multivariate recurrent events setting, where subjects may experience multiple types of recurrent events and some event types may be missing. We propose methods for the GART model that utilize the inverse probability weighting technique or the estimating equation projection strategy to handle event types that are missing at random. The new methods do not require imposing any parametric model for the missing mechanism, and thus are robust; moreover, they enjoy easy and stable implementation. We establish the uniform consistency and weak convergence of the resulting estimators and develop appropriate inferential procedures. Extensive simulation studies and an application to a dataset from Cystic Fibrosis Foundation Patient Registry (CFFPR) illustrate the validity and practical utility of the proposed methods.

Suggested Citation

  • Huijuan Ma & Limin Peng & Zhumin Zhang & HuiChuan J. Lai, 2018. "Generalized accelerated recurrence time model for multivariate recurrent event data with missing event type," Biometrics, The International Biometric Society, vol. 74(3), pages 954-965, September.
    • Handle: RePEc:bla:biomet:v:74:y:2018:i:3:p:954-965
    DOI: 10.1111/biom.12847
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    References listed on IDEAS

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    1. Yijian Huang & Limin Peng, 2009. "Accelerated Recurrence Time Models," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 36(4), pages 636-648, December.
    2. Feng-Chang Lin & Jianwen Cai & Jason P. Fine & Huichuan J. Lai, 2013. "Nonparametric estimation of the mean function for recurrent event data with missing event category," Biometrika, Biometrika Trust, vol. 100(3), pages 727-740.
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    8. Wang, Suojin & Wang, C. Y., 2001. "A note on kernel assisted estimators in missing covariate regression," Statistics & Probability Letters, Elsevier, vol. 55(4), pages 439-449, December.
    9. Li, Ruosha & Peng, Limin, 2014. "Varying coefficient subdistribution regression for left-truncated semi-competing risks data," Journal of Multivariate Analysis, Elsevier, vol. 131(C), pages 65-78.
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    12. Xiaoyan Sun & Limin Peng & Yijian Huang & HuiChuan J. Lai, 2016. "Generalizing Quantile Regression for Counting Processes With Applications to Recurrent Events," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 111(513), pages 145-156, March.
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    2. Xiaowei Sun & Jieli Ding & Liuquan Sun, 2020. "A semiparametric additive rates model for the weighted composite endpoint of recurrent and terminal events," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 26(3), pages 471-492, July.

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