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CRISPR-Cas9 System In Vivo Delivery to Combat HBV

Author

Listed:
  • Jahanzaib Ali
  • Husnain Aslam
  • Abida Yousuf

Abstract

Background: Hepatitis B Virus (HBV) infection remains a major global health issue despite the availability of HBV vaccine. The novel CRISPR-Cas9 gene editing technology efficiently helps to cure HBV by disruption or cleavage of HBV DNA. Aims: Several in vitro and in vivo studies have demonstrated the effectiveness of HBV-specific clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein 9 (CRISPR/Cas9) systems in cleaving HBV DNA. Methods: In vivo, delivery of the CRISPR/Cas9 system at target sites remains a major challenge that needs to be resolved before its clinical application in gene therapy for HBV. Results: In this review article, we comprehensively evaluate the progress, challenges, and therapeutic potential of CRISPR-Cas9 gene therapy for HBV using adeno-associated virus (AAV) vectors as delivery vehicles. Conclusion: The CRISPR-CAS9, HBV, AAV, delivery methods of CRISPR-CAS9 component in vivo, challenges, and future perspectives in harnessing this innovative technology to combat HBV infection.

Suggested Citation

  • Jahanzaib Ali & Husnain Aslam & Abida Yousuf, 2023. "CRISPR-Cas9 System In Vivo Delivery to Combat HBV," BIOEDUSCIENCE, Universitas Muhammadiyah Prof. Dr. Hamka, vol. 7(3), pages 339-349.
    • Handle: RePEc:apn:bionce:v:7:y:2023:i:3:p:339-349:id:12693
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    File URL: https://journal.uhamka.ac.id/index.php/bioeduscience/article/view/12693
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