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Elimination of cotinine from body fluids: Implications for noninvasive measurement of tobacco smoke exposure

Author

Listed:
  • Jarvis, M.J.
  • Russell, M.A.H.
  • Benowitz, N.L.
  • Feyerabend, C.

Abstract

Cotinine elimination from plasma, saliva, and urine was studied over 11 days in five subjects (three nonsmokers and two occasional smokers). Half-lives for cotinine averaged 16-19 hours in the different body fluids (range 10 to 27 hours between subjects). There was no tendency for the half-life in saliva to be longer than in plasma or urine. We conclude that choice of body fluid for cotinine assay in smoking studies should depend on practical rather than pharmacokinetic considerations.

Suggested Citation

  • Jarvis, M.J. & Russell, M.A.H. & Benowitz, N.L. & Feyerabend, C., 1988. "Elimination of cotinine from body fluids: Implications for noninvasive measurement of tobacco smoke exposure," American Journal of Public Health, American Public Health Association, vol. 78(6), pages 696-698.
  • Handle: RePEc:aph:ajpbhl:1988:78:6:696-698_0
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    Cited by:

    1. Kayla Rae Farrell & Emma Karey & Shu Xu & Grace Gibbon & Terry Gordon & Michael Weitzman, 2021. "E-Cigarette Use, Systemic Inflammation, and Depression," IJERPH, MDPI, vol. 18(19), pages 1-13, October.
    2. Won-Jun Choi & Ji-Won Lee & A Ra Cho & Yong-Jae Lee, 2019. "Dose-Dependent Toxic Effect of Cotinine-Verified Tobacco Smoking on Systemic Inflammation in Apparently Healthy Men and Women: A Nationwide Population-Based Study," IJERPH, MDPI, vol. 16(3), pages 1-11, February.
    3. Jacques J. Prignot, 2011. "Recent Contributions of Air- and Biomarkers to the Control of Secondhand Smoke (SHS): A Review," IJERPH, MDPI, vol. 8(3), pages 1-35, March.
    4. Jill E Johnston & Ellis Valentiner & Pamela Maxson & Marie Lynn Miranda & Rebecca C Fry, 2014. "Maternal Cadmium Levels during Pregnancy Associated with Lower Birth Weight in Infants in a North Carolina Cohort," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-9, October.
    5. Florian Fischer, 2016. "Challenges in Creating Evidence in Environmental Health Risk Assessments: The Example of Second-Hand Smoke," Challenges, MDPI, vol. 7(1), pages 1-9, January.
    6. James L. Repace & Alfred H. Lowrey, 1993. "An Enforceable Indoor Air Quality Standard for Environmental Tobacco Smoke in the Workplace," Risk Analysis, John Wiley & Sons, vol. 13(4), pages 463-475, August.
    7. James L. Repace & Jennifer Jinot & Steven Bayard & Karen Emmons & S. Katharine Hammond, 1998. "Air Nicotine and Saliva Cotinine as Indicators of Workplace Passive Smoking Exposure and Risk," Risk Analysis, John Wiley & Sons, vol. 18(1), pages 71-83, February.

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