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Targeting HK2 in Anticancer Therapy

Author

Listed:
  • Karolina Juszczak
  • Krzysztof Walczak

    (Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, Poland)

Abstract

Altered glucose metabolism is characteristic of many cancer cells, especially in the hypoxic zone of solid tumours, which is associated with a poor prognosis. Hexokinase (HK) is an enzyme involved in the first step of glycolysis, the phosphorylation of 6-OH in glucose molecules. Hexokinase 2 (HK2) is one of the isoforms overexpressed in cancer cells. In addition, HK2 binds to the voltage-dependent anion channel 1 (VDAC1) located on the outer mitochondrial membrane, protecting the cancer cell from apoptosis.

Suggested Citation

  • Karolina Juszczak & Krzysztof Walczak, 2024. "Targeting HK2 in Anticancer Therapy," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 56(3), pages 48032-48051, April.
    • Handle: RePEc:abf:journl:v:56:y:2024:i:3:p:48032-48051
    DOI: 10.26717/BJSTR.2024.56.008847
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