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Selective Peroxisome Proliferator-Activated Receptor-α Modulator K-877 Stimulated the Expression of ABCA1 in Pancreatic Beta Cells in a Glucotoxic State

Author

Listed:
  • Kensaku Fukunaga
  • Hitomi Imachi
  • Jiang Wenyi
  • Toshihiro Kobayashi
  • Takanobu Saheki
  • Takafumi Yoshimura
  • Hao Tian Zhang
  • Seisuke Sato
  • Nao Saheki
  • Koji Murao

    (Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan)

  • Jingya Lyu

    (Department of Physiology, School of Medicine, Jinan University, China)

Abstract

ATP-binding cassette protein A1 (ABCA1) is a critical regulator of cholesterol and phospholipid efflux from cells to HDL. Additionally, ABCA1 is important for insulin secretion, as evidenced by impaired glucose tolerance and decreased insulin secretion in mice lacking ABCA1 in pancreatic β cells. Long-term hyperglycemia in type 2 diabetes mellitus, a phenomenon that causes dysfunction of pancreatic β-cells and insulin resistance, is called “glucotoxicity†and is clinically important as it aggravates diabetes. Here, we investigated the effects of pemafibrate (K-877), a novel selective PPARα modulator, on insulin secretion under glucotoxic conditions.

Suggested Citation

  • Kensaku Fukunaga & Hitomi Imachi & Jiang Wenyi & Toshihiro Kobayashi & Takanobu Saheki & Takafumi Yoshimura & Hao Tian Zhang & Seisuke Sato & Nao Saheki & Koji Murao & Jingya Lyu, 2024. "Selective Peroxisome Proliferator-Activated Receptor-α Modulator K-877 Stimulated the Expression of ABCA1 in Pancreatic Beta Cells in a Glucotoxic State," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 56(2), pages 47904-47913, April.
    • Handle: RePEc:abf:journl:v:56:y:2024:i:2:p:47904-47913
    DOI: 10.26717/BJSTR.2024.56.008829
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