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Mode-of-Action of Antimicrobial Peptides

Author

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  • Mihai-Darius Cernescu
  • Ioana Grozea
  • Monica Butnariu

    (University of Life Sciences “King Mihai I†from Timisoara, Romania)

Abstract

Antimicrobial peptides (AMPs) are natural antibiotics, synthesized by ribosomes, with an effect on the natural immunity of animal organisms. AMPs differ in composition [sequence and type of amino acids (AAs)] and structure, which contribute to rapid lysis and have a varied spectrum of antimicrobial activity. AMPs are: peptides (Pps) with alpha-helix structure (i.e., cecropins, magainins, mellitin, etc.); cyclic Pps and ring with several cysteine residues (i.e., defensins, protegrins, etc.); Pps rich in one or another AA (i.e., proline argininerich PR39, histidine, glycine, etc.). Most AMPs are characterized by hydrophobic and cationic properties, adopt an amphipathic structure (alpha-helix, spiral beta or alpha-helix / spiral beta), which is essential for antimicrobial activity.

Suggested Citation

  • Mihai-Darius Cernescu & Ioana Grozea & Monica Butnariu, 2024. "Mode-of-Action of Antimicrobial Peptides," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 56(2), pages 47878-47882, April.
    • Handle: RePEc:abf:journl:v:56:y:2024:i:2:p:47878-47882
    DOI: 10.26717/BJSTR.2024.56.008824
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