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Susceptibility MRI in Brain Nuclei Improves Early Diagnosis of Parkinson’s Disease Using Linear Discriminant Analysis Method

Author

Listed:
  • Jian Zhang Xia
  • Hai Mei Huang

    (Department of Radiology, Fifth People’s Hospital of NanHai District, China)

  • Ya Bin Jin

    (Department of Clinical Research Institute, First People’s Hospital of Foshan, China)

  • Yun Jie Rong

    (Department of Radiology, Second Affiliated Hospital of Shantou University Medical College, China)

  • Wen Xiu Wu
  • Ming Yong Gao
  • Hai Mei Huang
  • Zhi Feng Xu

    (Department of Radiology, First People’s Hospital of Foshan, China)

Abstract

The study aimed to explore a new imaging biomarker based on quantitative susceptibility mapping (QSM) using linear discriminant analysis (LDA) method for improving early diagnosis of Parkinson’s disease. 34 PD patients and 15 controls were enrolled, and the PD patients were divided into two groups (early-stage and advanced-stage groups) based on the Hoehn-Yahr assessment. Magnetic susceptibilities in six brain structures, including the caudate nucleus (CN), globus pallidus (GP), thalamus (THA), putamen (PUT), substantia nigra (SN) and red nucleus (RN), were measured. Mean susceptibilities were measured and compared between the PD patients and controls.

Suggested Citation

  • Jian Zhang Xia & Hai Mei Huang & Ya Bin Jin & Yun Jie Rong & Wen Xiu Wu & Ming Yong Gao & Hai Mei Huang & Zhi Feng Xu, 2024. "Susceptibility MRI in Brain Nuclei Improves Early Diagnosis of Parkinson’s Disease Using Linear Discriminant Analysis Method," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 55(4), pages 47249-47257, March.
    • Handle: RePEc:abf:journl:v:55:y:2024:i:4:p:47249-47257
    DOI: 10.26717/BJSTR.2024.55.008740
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