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Reaction to Azithromycin, Between Hypereosinophilia and Charcot- Leyden Crystals- Case Report of a Pediatric Case

Author

Listed:
  • M Martini

    (Pediatric Unit, S. Donato Hospital, Arezzo, Italy)

  • A Ariano

    (Pediatric Unit, Azienda Ospedaliera Universitaria Siena, Italy)

  • E Parisio

    (Microbiology Unit S.Donato Hospital, Arezzo , Italy)

Abstract

The Charcot-Leyden (CL) crystals, needle-shaped bipyramidal crystals, are present contextually with a high tissue infiltration of eosinophils. They are formed when galectin-10 crystalises at an intracellular or extracellular level during eosinophilic ETosis* (*Extracellular Trap cell death), an active cell death process involving the destruction of the cell nucleus and plasma membrane with the release of chromatin structures similar to cobwebs [1-3]. Hypereosinophilia, or rather, an eosinophilic count greater than 1.5 x 10^9/L, is typical in cases of hypersensitivity. An exemplary case that caught our attention in July 2023, was that of M., a 4-year-old girl with gastrointestinal symptoms combined with an elevated degree of eosinophilia equal to a count of 18.66*10^9/L and Charcot-Leyden crystals taken from a stool sample.

Suggested Citation

  • M Martini & A Ariano & E Parisio, 2024. "Reaction to Azithromycin, Between Hypereosinophilia and Charcot- Leyden Crystals- Case Report of a Pediatric Case," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 55(4), pages 47199-47202, March.
    • Handle: RePEc:abf:journl:v:55:y:2024:i:4:p:47199-47202
    DOI: 10.26717/BJSTR.2024.55.008733
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