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Cluster Analysis of RNA m6A Methylation Regulators Based on TCGA and GEO Database in Hepatocellular Carcinoma

Author

Listed:
  • Xiaoshi Zhang
  • Jianqiang Cai

    (National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China)

  • Zhuo Yu

    (Beijing Hospital, China)

  • Xiaoyi Zhang

    (Exchange, Development & Service Center for Science & Technology Talents, China)

Abstract

As potential targets and candidate molecules for the treatment of cancer, m6 A RNA and its regulator genes have important application prospects in individualized therapy of Hepatocellular Carcinoma(HCC). Through TCGA and GEO data screening, we demonstrated the expression of different m6 A regulators within HCC related to genetic variation, biological pathways and patients’ prognosis. We use machine learning methods to cluster m6 A regulators and differential expressed genes, which may provide a theoretical basis for the establishment of a risk assessment model.

Suggested Citation

  • Xiaoshi Zhang & Jianqiang Cai & Zhuo Yu & Xiaoyi Zhang, 2024. "Cluster Analysis of RNA m6A Methylation Regulators Based on TCGA and GEO Database in Hepatocellular Carcinoma," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 55(3), pages 47045-47054, March.
    • Handle: RePEc:abf:journl:v:55:y:2024:i:3:p:47045-47054
    DOI: 10.26717/BJSTR.2024.55.008713
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