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tiff Person Syndrome- Taxonomic Analysis Supports Use of Large Data Methods to Appraise Major Comorbidities of a Rare Disorder

Author

Listed:
  • Beth B Hogans

    (Geriatric Research, Education, and Clinical Center (GRECC), USA
    Department of Neurology, Johns Hopkins School of Medicine, USA)

  • Bernadette C Siaton

    (Geriatric Research, Education, and Clinical Center (GRECC), USA
    Department of Medicine, Division of Rheumatology, University of Maryland School of Medicine, USA)

  • Les I Katzel

    (Geriatric Research, Education, and Clinical Center (GRECC), USA
    Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Maryland School of Medicine, USA)

  • John D Sorkin

    (Geriatric Research, Education, and Clinical Center (GRECC), USA
    Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Maryland School of Medicine, USA)

Abstract

Stiff-person syndrome (SPS), a rare neuro-immunological condition producing profound and insidious stiffness, often manifests with marked elevation of autoantibodies to glutamic acid decarboxylase-65 (GAD65 Abs). Patient sparsity has impeded understanding of SPS. We sought to characterize SPS features in a representative sample of U.S. older adults, using unbiased large data methods, with validation.

Suggested Citation

  • Beth B Hogans & Bernadette C Siaton & Les I Katzel & John D Sorkin, 2024. "tiff Person Syndrome- Taxonomic Analysis Supports Use of Large Data Methods to Appraise Major Comorbidities of a Rare Disorder," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 55(2), pages 46785-46797, February.
    • Handle: RePEc:abf:journl:v:55:y:2024:i:2:p:46785-46797
    DOI: 10.26717/BJSTR.2024.55.008673
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