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The Influence of Protein Loading in Emptied Yeast on its Bactericidal and Anticancer Effectiveness

Author

Listed:
  • Nawal Abd El-Baky
  • Mona M Sharaf
  • Amro A Amara

    (Protein Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technological Applications (SRTA-City), Egypt)

Abstract

While yeasts were employed for delivery of drugs, active RNA or DNA, they were in minor cases utilized in delivery of certain antigenic proteins. The loading of bioeffective proteins inside emptied cells can preserve their structure and bioefficiency. In the present work, loaded lactoferrin inside emptied yeast was assayed for bactericidal and anticancer effectiveness after loading and compared with free protein. Its bactericidal efficiency was assayed against S. aureus, S. typhi, K. pneumonia, S. sonnei, P. vulgaris, S. marcescens, and E. coli. Its cytotoxicity was checked on human skin fibroblast (HSF) and potential anticancer impact on epidermoid skin carcinoma of human (A-431).

Suggested Citation

  • Nawal Abd El-Baky & Mona M Sharaf & Amro A Amara, 2024. "The Influence of Protein Loading in Emptied Yeast on its Bactericidal and Anticancer Effectiveness," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 55(1), pages 46542-46548, February.
    • Handle: RePEc:abf:journl:v:55:y:2024:i:1:p:46542-46548
    DOI: 10.26717/BJSTR.2024.55.008635
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