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Results of Genetic Studies of Adolescents with Idiopathic Hypogonadotropic Hypogonadism

Author

Listed:
  • Alieva DA, Mavlonov U Kh
  • Mavlonov U Kh
  • Saydakhmedova MU
  • Khudaybergenov Sh A
  • Boboev KT
  • Urmanova Yu M

    (Republican Specialized Scientific and Practical Medical Center of Endocrinology of the Ministry of Health of the Republic of Uzbekistan named after academician. Y.H. Turakulova, Department of Neuroendocrinology, Tashkent Pediatric Medical Institute, Department of Endocrinology, Pediatric Endocrinology, Department of Surgical Diseases, Bukhara Regional Endocrinological Dispensary, Republican Specialized Scientific and Practical Medical Center for Hematology, Republic of Uzbekistan)

Abstract

Gonadotropin releasing hormone (GnRH) is the main hormone of the reproductive endocrine system. The existence of central hormones regulating reproduction was postulated a century ago [1]. In 1910, Crowe et al. [2]. demonstrated that disruption of the hypothalamic-pituitary connection in dogs prevents the onset of puberty. Subsequent studies led to the hypothesis that the pituitary gland is controlled by the hypothalamic factor [3-6]. However, it was not until 1971 that the amino acid sequence of GnRH was determined after extraction from the hypothalamus of thousands of pigs and sheep by the groups of Chally and Guillemin [7,8].

Suggested Citation

  • Alieva DA, Mavlonov U Kh & Mavlonov U Kh & Saydakhmedova MU & Khudaybergenov Sh A & Boboev KT & Urmanova Yu M, 2024. "Results of Genetic Studies of Adolescents with Idiopathic Hypogonadotropic Hypogonadism," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 54(5), pages 46474-46479, February.
    • Handle: RePEc:abf:journl:v:54:y:2024:i:5:p:46474-46479
    DOI: 10.26717/BJSTR.2024.54.008624
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