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Prognostic Value of Proliferation Markers Ki-67 and p53 in Patients with Recurrent Macro- and Giant NonFunctional Pituitary Tumors

Author

Listed:
  • Mirtukhtaeva MB

    (Endocrinologist of the Department of Neuroendocrinology with Pituitary Surgery RSNPMCE Ministry of Health of the Republic of Uzbekistannamed after academician Y.H. Turakulova, Uzbekistan)

  • Khudaybergenov Sh A

    (Doctor of Medical Sciences, Professor of the Department of Endocrinology, Pediatric Endocrinology Tash PMI, Uzbekistan)

  • Saydakhmedova MU

    (Head of the Department of Physiotherapy, RSNPMCE, Ministry of Health of the Republic of Uzbekistannamed after academician Y.H. Turakulova, Uzbekistan)

  • Urmanova Yu M

    (Department of Surgical Diseases, TashPMI, Uzbekistan)

  • Alieva DA

    (3rd year Master of Study at TashPMI, Department of Endocrinology, Pediatric Endocrinology, Tash PMI, Uzbekistan)

Abstract

Non-functional pituitary adenomas (NFPA) are the most common type of pituitary macroadenomas, accounting for 25–35% of all cases [1]. They are usually benign, but many infiltrate the sphenoid sinus, cavernous sinus, or dura mater and cannot be completely removed by surgical resection. Because residual cells retain the ability to proliferate, residual tumors may re-proliferate, requiring new therapeutic interventions [2]. Most relapses occur within five years after surgery. Due to the high rate of distant relapses, the prognosis for patients is not always favorable: surgery is the main treatment for NFPA, and there is currently no effective pharmacological treatment for NFPA [3,4].

Suggested Citation

  • Mirtukhtaeva MB & Khudaybergenov Sh A & Saydakhmedova MU & Urmanova Yu M & Alieva DA, 2024. "Prognostic Value of Proliferation Markers Ki-67 and p53 in Patients with Recurrent Macro- and Giant NonFunctional Pituitary Tumors," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 54(5), pages 46470-46473, February.
    • Handle: RePEc:abf:journl:v:54:y:2024:i:5:p:46470-46473
    DOI: 10.26717/BJSTR.2024.54.008623
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