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Case Series of Ceftriaxone-Induced Neutropenia and Leukopenia- Experience in Outpatient Parenteral Antimicrobial Therapy (OPAT) Setting

Author

Listed:
  • Sue Wen Leo

    (Antimicrobial and High Cost Drugs Pharmacist, Co-lead of OPAT Service at United Lincolnshire Hospitals NHS Trust, UK)

  • Isabel Sze Wing Fok

    (Specialist Clinical Pharmacist – Intestinal Failure, Nottingham University Hospitals NHS Trust, UK)

  • Swapna R Motukupally

    (Locum Consultant Microbiologist, Pathlinks, North Lincolnshire & Goole NHS Foundation Trust, United Lincolnshire Hospitals NHS Trust, UK)

  • Karen Fan

    (Antimicrobial Admin Support at United Lincolnshire Hospitals NHS Trust, UK)

  • Freeman Wu

    (Antimicrobials and OPAT Operational Lead Pharmacist, United Lincolnshire Hospitals NHS Trust, UK)

Abstract

Ceftriaxone is a commonly used antibiotic to treat a range of infections, particularly for central nervous system, skin and soft tissues as well as bone and joint infections. The course length of ceftriaxone for these indications can range between 2 to 6 weeks in both hospital and outpatient parenteral antimicrobial therapy (OPAT) settings. With prolonged courses being used, coupled with the general understanding that beta-lactam antibiotics are safer than other classes of antibiotics, there is a need for increasing awareness of safety of ceftriaxone, particularly on rarer but more serious adverse effects, such as neutropenia and leukopenia, which may lead to clinical complications.

Suggested Citation

  • Sue Wen Leo & Isabel Sze Wing Fok & Swapna R Motukupally & Karen Fan & Freeman Wu, 2024. "Case Series of Ceftriaxone-Induced Neutropenia and Leukopenia- Experience in Outpatient Parenteral Antimicrobial Therapy (OPAT) Setting," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 54(4), pages 46202-46208, January.
    • Handle: RePEc:abf:journl:v:54:y:2024:i:4:p:46202-46208
    DOI: 10.26717/BJSTR.2024.54.008591
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