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A Blood Biomarker Panel Recommended for Personalized Prediction, Prognosis and Prevention of Rheumatoid Arthritis

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  • Radka Fuchsova

    (Department of Immunochemistry Diagnostics, University Hospital and Faculty of Medicine in Pilsen, Charles University, Czech Republic)

Abstract

Rheumatoid arthritis (RA) is the most common chronic autoimmune joint disease affecting synovial tissue in multiple joints. The course of RA can be very heterogeneous and patients with the same diagnosis can present with different symptoms and outcomes as well as the possible development of irreversible joint damage leading to loss of function. Evidence suggests that RA develops in 3 phases: an asymptomatic period of genetic risk, a pre-clinical period in which RA-related antibodies can be detected, and a clinical phase with the clinical symptoms of inflammatory arthritis. Early detection of RA and the availability of biologic agents have markedly improved outcomes in these patients [1]. At present, composite indices (mostly DAS28, Disease Activity Index) are used to monitor the activity of the disease. They include clinical parameters (tender and swollen joints), and two laboratory parameters of inflammation: C reactive protein (CRP) and erythrocyte sedimentation rate parameter (ESR). The disadvantage of these scores is.

Suggested Citation

  • Radka Fuchsova, 2023. "A Blood Biomarker Panel Recommended for Personalized Prediction, Prognosis and Prevention of Rheumatoid Arthritis," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 50(2), pages 41580-41583, May.
    • Handle: RePEc:abf:journl:v:50:y:2023:i:2:p:41580-41583
    DOI: 10.26717/BJSTR.2023.50.007938
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